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Electronic and hand\u2010searches identified relevant papers, which were screened and evaluated for inclusion. Full\u2010papers were retrieved and relevant information was extracted (also plaque indices), including quality and risk of bias. Mean treatment effects were calculated to obtain weighted mean differences (<jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content>) and 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the process of screening and selection, 87 articles with 133 comparisons, were included in the review. The additional effects of the tested products were statistically significant in terms of L\u00f6e &amp; Silness gingival index (46 comparisons, <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> \u22120.217), modified gingival index (<jats:italic>n<\/jats:italic>\u00a0=\u00a023, \u22120.415), gingivitis severity index (<jats:italic>n<\/jats:italic>\u00a0=\u00a026, \u221214.939%) or bleeding index (<jats:italic>n<\/jats:italic>\u00a0=\u00a023, \u22127.626%), with significant heterogeneity. For plaque, additional effects were found for Turesky (66 studies, <jats:styled-content style=\"fixed-case\">WMD<\/jats:styled-content> \u22120.475), Silness &amp; L\u00f6e (<jats:italic>n<\/jats:italic>\u00a0=\u00a026, \u22120.109), and plaque severity (<jats:italic>n<\/jats:italic>\u00a0=\u00a012, \u221223.4%) indices, with significant heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of the present study, formulations with specific agents for chemical plaque control provide statistically significant improvements in terms of gingival, bleeding and plaque indices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12331","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T15:24:49Z","timestamp":1418311489000},"source":"Crossref","is-referenced-by-count":149,"title":["Efficacy of adjunctive anti\u2010plaque chemical agents in managing gingivitis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Jorge","family":"Serrano","sequence":"first","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Escribano","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conchita","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herrera","sequence":"additional","affiliation":[{"name":"ETEP (Etiology and Therapy of Periodontal Diseases) Research Group University Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1986.tb01509.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01013.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2010.00478.x"},{"key":"e_1_2_6_5_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.255"},{"key":"e_1_2_6_7_1","first-page":"59","article-title":"The clinical efficacy of colgate total plus whitening toothpaste containing a special grade of silica and colgate total fresh stripe toothpaste in the control of plaque and gingivitis: a six\u2010month clinical study","volume":"13","author":"Allen D. 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