{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:52:09Z","timestamp":1788871929148,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ITI Research","award":["813_2012"],"award-info":[{"award-number":["813_2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Vitamin D deficiency is considered to diminish bone regeneration. Yet, raising the serum levels takes months. A topic application of the active vitamin D metabolite, calcitriol, may be an effective approach. Thus, it becomes important to know the effect of vitamin D deficiency and local application on alveolar bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Sixty rats were divided into three groups; two vitamin depletion groups and a control group. Identical single defects (2\u00a0mm diameter) were created in the maxilla and mandible treated with calcitriol soaked collagen in one deficiency group while in the other two groups not. Histomorphometric analysis and micro\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      s were performed after 1 and 3\u00a0weeks. Serum levels of 25(\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      )D\n                      <jats:sub>3<\/jats:sub>\n                      and\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      were determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Bone formation rate significantly increased within the observation period in all groups. Bone regeneration was higher in the maxilla than in the mandible. However, bone regeneration was lower in the control group compared to vitamin depletion groups, with no significant effects by local administration of calcitriol (micro\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      mandible\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003, maxilla\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001; histomorphometry maxilla\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.035, mandible\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency not necessarily impairs bone regeneration in the rat jaw and a single local calcitriol application does not enhance healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12342","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T04:26:57Z","timestamp":1417580817000},"page":"96-103","source":"Crossref","is-referenced-by-count":17,"title":["Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats"],"prefix":"10.1111","volume":"42","author":[{"given":"Alexander","family":"F\u00fcgl","sequence":"first","affiliation":[{"name":"Department of Oral Surgery Medical University of Vienna Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery Medical University of Vienna Vienna Austria"},{"name":"Austrian Cluster for Tissue Regeneration Vienna Austria"},{"name":"Laboratory of Oral 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