{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:12:31Z","timestamp":1780449151647,"version":"3.54.1"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim is to assess the effect of desensitizing toothpaste on dentin hypersensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, <jats:styled-content style=\"fixed-case\">CENTRAL<\/jats:styled-content>, and Embase on December 20, 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 626 articles searched, a total of 31 randomized controlled clinical trials were included. The Standardized mean differences (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>) for potassium\u2010containing toothpaste (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) was \u22121.28 (95% Confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) \u22122.05 to \u22120.51; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a093%); Stannous fluoride\u2010 (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) was \u22121.37 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22122.30 to \u22120.44; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a095%); Potassium and stannous fluoride\u2010 (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) was \u22122.50 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22124.10 to \u22120.91; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a095%); Calcium sodium phosphosilicate<jats:bold>\u2010<\/jats:bold> (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) was \u22122.36 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22123.72 to \u22121.00; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a092%); Arginine\u2010 (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) was \u22123.25 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22123.87 to \u22122.63; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a086%). The desensitizing effect was favoured in the intervention group treated with potassium\u2010, stannous fluoride\u2010, potassium and stannous fluoride\u2010, calcium sodium phosphosilicate\u2010, and arginine\u2010containing toothpaste compared to placebo. Whereas, strontium\u2010containing toothpaste (<jats:styled-content style=\"fixed-case\">SMD<\/jats:styled-content>, 0.05; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, \u22120.34 to 0.44; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a064%) was found to have no statistically significant desensitizing effect in the meta\u2010analysis of four studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study reports that there is sufficient evidence to support the use of potassium\u2010, stannous fluoride\u2010, potassium and stannous fluoride\u2010, calcium sodium phosphosilicate\u2010, and arginine\u2010containing desensitizing toothpastes for dentin hypersensitivity, but not the use of strontium\u2010containing desensitizing toothpaste.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12347","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T03:47:31Z","timestamp":1418096851000},"page":"131-141","source":"Crossref","is-referenced-by-count":84,"title":["Desensitizing toothpaste <i>versus<\/i> placebo for dentin hypersensitivity: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Ji\u2010Hyun","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry Section of Dentistry Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Section of Dentistry Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Kwon","family":"Myung","sequence":"additional","affiliation":[{"name":"Family Medicine Clinic and Center for Cancer Prevention and Detection (Hospital) Cancer Epidemiology Branch (Research Institute) Research Institute National Cancer Center 2 Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(87)90045-5"},{"key":"e_1_2_7_3_1","first-page":"115","article-title":"Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450\u00a0ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450\u00a0ppm fluoride, and to a control toothpaste with 1450\u00a0ppm fluoride: A three\u2010day clinical study in mississauga, Canada","volume":"20","author":"Ayad F.","year":"2009","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1963.0104"},{"key":"e_1_2_7_5_1","first-page":"14A","article-title":"Assessment of hypersensitivity reduction of a dentifrice containing 0.3% triclosan, 2.0% PVM\/MA copolymer, 0.243% NaF and specially\u2010designed silica as compared to a dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate and zinc lactate and to a dentifrice containing 0.243% NaF on dentin hypersensitivity reduction: an 8\u2010week study","volume":"24","author":"Chaknis P.","year":"2011","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00463.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1525\/ae.2004.31.4.475"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.12.720"},{"key":"e_1_2_7_9_1","first-page":"17","article-title":"Comparative investigation of the desensitizing efficacy of a new dentifrice: a 14\u2010day clinical study","volume":"27","author":"Conforti N.","year":"2000","journal-title":"Compendium of Continuing Education in Dentistry. 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