{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:04:12Z","timestamp":1790841852317,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T00:00:00Z","timestamp":1424390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim was to evaluate the effects of recombinant human platelet\u2010derived growth factor\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content> (rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>) and recombinant human fibroblast growth factor\u20102 (rh<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102) on treating periodontal intra\u2010bony defects, compared to the control (carrier alone).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic and hand searches were performed to identify eligible studies. The weighed mean differences of linear defect fill (<jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) reduction, clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) gain and gingival recession (<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>) were calculated using random effect meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The searches yielded 1018 articles, of which seven studies were included. Only one included study was considered at low risk of bias. The outcomes that reached statistical significance in comparison to carriers alone included: <jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content> (0.95\u00a0mm, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.62\u20131.28\u00a0mm or 20.17%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 11.81\u201328.54%) and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain (0.34\u00a0mm, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.03\u20130.65\u00a0mm) for <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content> (21.22%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 5.82\u201336.61%) for <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limits of this review, rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content> demonstrated significantly more <jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain; rh<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 resulted in significantly higher percentage of <jats:styled-content style=\"fixed-case\">LDF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12354","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T09:21:43Z","timestamp":1421832103000},"page":"272-280","source":"Crossref","is-referenced-by-count":73,"title":["Outcomes of regenerative treatment with rh<scp>PDGF<\/scp>\u2010<scp>BB<\/scp> and rh<scp>FGF<\/scp>\u20102 for periodontal intra\u2010bony defects: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Vahid","family":"Khoshkam","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"},{"name":"Currently Advanced Periodontology Program Herman Ostrow School of Dentistry University of Southern California Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun\u2010Liang","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Hao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mailoa","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-9746","authenticated-orcid":false,"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI 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