{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:51:49Z","timestamp":1788277909183,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Homocysteine (Hcy) is implicated in the development of cardiovascular diseases (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>). The effect of periodontal disease and periodontal therapy on plasma Hcy remains controversial. Hence, in this pilot study we assessed the effect of periodontal disease and non\u2010surgical periodontal therapy (<jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content>) on plasma Hcy in systemically healthy Indian subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Forty participants (30 to 39\u00a0years) were enrolled in the study and were divided into two groups based on gingival index, probing depth, and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>): Healthy (control group; <jats:italic>n<\/jats:italic>\u00a0=\u00a020) and Chronic Periodontitis (test group; <jats:italic>n<\/jats:italic>\u00a0=\u00a020). Plasma samples were collected and quantified at baseline and 12\u00a0weeks after scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) for Hcy using High Performance Liquid Chromatography with fluorescent detection (<jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>\u2010fld).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma Hcy levels of chronic periodontitis (17.87\u00a0\u00b1\u00a01.21\u00a0<jats:italic>\u03bc<\/jats:italic>mol\/l) subjects was significantly higher than healthy subjects (9.09\u00a0\u00b1\u00a02.11\u00a0<jats:italic>\u03bc<\/jats:italic>mol\/l). Post\u2010therapy, the plasma Hcy concentration reduced significantly (11.34\u00a0\u00b1\u00a01.87\u00a0<jats:italic>\u03bc<\/jats:italic>mol\/l) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rise and descent of plasma Hcy levels with periodontal inflammation and therapy, respectively, indicate a direct relationship of Hcy with chronic periodontitis. <jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content> may be employed as an adjunctive Hcy Lowering Therapy, contributing towards primary prevention against <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>'s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12374","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T06:45:37Z","timestamp":1422600337000},"page":"221-227","source":"Crossref","is-referenced-by-count":15,"title":["Effect of non\u2010surgical periodontal therapy on plasma homocysteine levels in Indian population with chronic periodontitis: a pilot study"],"prefix":"10.1111","volume":"42","author":[{"given":"Smiti","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"Department of Periodontics Krishnadevaraya College of Dental Sciences and Hospital Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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