{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:13Z","timestamp":1787015353949,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"S16","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Focused question<\/jats:title>\n \n What is the effect of a dentifrice (\n DF<\/jats:styled-content>\n ), a mouthwash (\n MW<\/jats:styled-content>\n ), tongue cleaning (\n TC<\/jats:styled-content>\n ), or any combination of these as adjunct to toothbrushing on intra\u2010oral malodour and tongue coating as compared to toothbrushing alone in systemically healthy patients, when used for a minimum follow\u2010up period of 2\u00a0weeks?\n <\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n The\n MEDLINE<\/jats:styled-content>\n \u2010\n P<\/jats:styled-content>\n ub\n M<\/jats:styled-content>\n ed,\n C<\/jats:styled-content>\n ochrane\u2010\n CENTRAL<\/jats:styled-content>\n and\n EMBASE<\/jats:styled-content>\n databases were searched up to\n A<\/jats:styled-content>\n ugust 2014. Measurements of\n V<\/jats:styled-content>\n olatile\n S<\/jats:styled-content>\n ulphur\n C<\/jats:styled-content>\n ompounds and organoleptic scores of oral malodour were selected as outcome variables. Data were extracted and a descriptive analysis was performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Independent screening of 1054 unique papers resulted in 12 eligible clinical trials with a medium\u2010term (\u22652\u00a0weeks) duration. The majority of studies provided a significant reduction in oral malodour when evaluating products with an active ingredient (incorporated into a\n DF<\/jats:styled-content>\n or a\n MW<\/jats:styled-content>\n ) used adjunctively to toothbrushing. The added value of tongue cleaning over a\n MW<\/jats:styled-content>\n was evaluated in one study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Due to very limited evidence, the potential effect of a specifically formulated dentifrice, a mouthwash or a tongue scraper for treating oral malodour is, in general, unclear. For mouthwashes containing the active ingredients chlorhexidine\u00a0+\u00a0cetylpyridinium chloride\u00a0+\u00a0zinc (\n CHX<\/jats:styled-content>\n \u00a0+\u00a0\n CPC<\/jats:styled-content>\n \u00a0+\u00a0\n Z<\/jats:styled-content>\n n) and zinc chloride\u00a0+\u00a0cetylpyridinium chloride (ZnCl\u00a0+\u00a0\n CPC<\/jats:styled-content>\n ) most evidence was available. The strength of a recommendation to use these products was graded to be \u2018weak\u2019.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12378","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T05:33:22Z","timestamp":1423805602000},"source":"Crossref","is-referenced-by-count":50,"title":["Treatment of oral malodour. Medium\u2010term efficacy of mechanical and\/or chemical agents: a systematic review"],"prefix":"10.1111","volume":"42","author":[{"given":"Dagmar E.","family":"Slot","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"De Geest","sequence":"additional","affiliation":[{"name":"Periodontology Department of Oral Health Sciences Katholieke Universiteit Leuven University Hospitals & Dentistry Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fridus A.","family":"van der Weijden","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry Amsterdam (ACTA) Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Periodontology Department of Oral Health Sciences Katholieke Universiteit Leuven University Hospitals & Dentistry Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0728-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.635601"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2012.00546.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijos.2012.39"},{"key":"e_1_2_8_6_1","first-page":"531","article-title":"The effect of four mouthrinses on oral malodour","volume":"23","author":"Borden L. 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