{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:09:16Z","timestamp":1787015356134,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001722","name":"Royal Netherlands Academy of Arts and Sciences","doi-asserted-by":"crossref","award":["CEP-10CDP025"],"award-info":[{"award-number":["CEP-10CDP025"]}],"id":[{"id":"10.13039\/501100001722","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81371170"],"award-info":[{"award-number":["81371170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Doctoral Fund of Ministry of Education of China","award":["20120141130009"],"award-info":[{"award-number":["20120141130009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The implantation of bone marrow\u2010derived mesenchymal stem cells (\n                      <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                      s) has previously been shown successful to achieve periodontal regeneration. However, the preferred pre\u2010implantation differentiation strategy (e.g. maintenance of stemness, osteogenic or chondrogenic induction) to obtain optimal periodontal regeneration is still unknown. This in\u00a0vivo study explored which differentiation approach is most suitable for periodontal regeneration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Mesenchymal stem cells were obtained from Fischer rats and seeded onto poly(lactic\u2010co\u2010glycolic acid)\/poly(\n                      <jats:italic>\u025b<\/jats:italic>\n                      \u2010caprolactone) electrospun scaffolds, and then pre\u2010cultured under different in\u00a0vitro conditions: (i) retention of multilineage differentiation potential; (ii) osteogenic differentiation approach; and (iii) chondrogenic differentiation approach. Subsequently, the cell\u2010scaffold constructs were implanted into experimental periodontal defects of Fischer rats, with empty scaffolds as controls. After 6\u00a0weeks of implantation, histomorphometrical analyses were applied to evaluate the regenerated periodontal tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The chondrogenic differentiation approach showed regeneration of alveolar bone and ligament tissues. The retention of multilineage differentiation potential supported only ligament regeneration, while the osteogenic differentiation approach boosted alveolar bone regeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Chondrogenic differentiation of\n                      <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>\n                      s before implantation is a useful strategy for regeneration of alveolar bone and periodontal ligament, in the currently used rat model.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12379","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T05:54:57Z","timestamp":1424238897000},"page":"380-389","source":"Crossref","is-referenced-by-count":51,"title":["Influence of bone marrow\u2010derived mesenchymal stem cells pre\u2010implantation differentiation approach on periodontal regeneration\n                    <i>in\u00a0vivo<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Xinjie","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"},{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"},{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A. W.","family":"Oortgiesen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Frank","family":"Walboomers","sequence":"additional","affiliation":[{"name":"Department of Biomaterials Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.12.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(03)00138-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31082"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102474\u201012\u201031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2009.0712"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.05.052"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.469"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050341"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509340867"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2012.00443.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.9.1281"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300106"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000166547"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/81395"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2009.00303.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.787"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.02.005"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001724.pub2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2012.01877.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000302107"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10126"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512452430"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomat\u2010erials.2011.04.071"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5777"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.10.003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.06.026"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12113"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22538"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:24:41Z","timestamp":1696260281000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jcpe.12379"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12379","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,12]]}}}