{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:19:27Z","timestamp":1792606767347,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,31]],"date-time":"2015-03-31T00:00:00Z","timestamp":1427760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the 1\u2010year outcome of Minimally Invasive Single Implant Treatment (M.I.S.I.T.) based on ridge preservation and contour augmentation in patients with a high aesthetic risk profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Periodontally healthy non\u2010smoking patients with a failing tooth in the anterior maxilla (15\u201325) were selected. All were in need of a single implant and demonstrated high risk for aesthetic complications given mid\u2010facial recession at the failing tooth and\/or a buccal bone dehiscence and\/or a thin\u2010scalloped gingival biotype. Patients without mid\u2010facial recession (<jats:styled-content style=\"fixed-case\">NRG<\/jats:styled-content>) received flapless tooth extraction and ridge preservation using a collagen\u2010enriched bovine\u2010derived xenograft, flapless installation of a bone condensing implant with variable\u2010thread design (4\u20136\u00a0months later), a provisional screw\u2010retained crown and connective tissue graft (<jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content>) inserted in the buccal mucosa (3\u00a0months later) and a permanent crown (3\u00a0months later). Patients with mid\u2010facial recession (<jats:styled-content style=\"fixed-case\">RG<\/jats:styled-content>) were treated similarly, yet they received a <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> at the time of ridge preservation. All patients were treated by an experienced periodontist using a microsurgical approach. Primary outcome variables included papillary and mid\u2010facial recession. Clinical parameters, pink (<jats:styled-content style=\"fixed-case\">PES<\/jats:styled-content>) and white aesthetic score (<jats:styled-content style=\"fixed-case\">WES<\/jats:styled-content>) were considered secondary outcome variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty patients (25 females, 25 males; mean age 39, range 19\u201381; 42 in <jats:styled-content style=\"fixed-case\">NRG<\/jats:styled-content> and 8 in <jats:styled-content style=\"fixed-case\">RG<\/jats:styled-content>) met the selection criteria and consented to the treatment. Forty\u2010seven could be examined at 12\u00a0months and all implants survived. Mean bone loss amounted to 0.48\u00a0mm (range 0.00\u20131.80) at 12\u00a0months. Papillary recession was minimal in both groups at 12\u00a0months (mean\u00a0\u2264\u00a00.3\u00a0mm), as was mid\u2010facial recession in the <jats:styled-content style=\"fixed-case\">NRG<\/jats:styled-content> (mean 0.1\u00a0mm). Twelve patients in the <jats:styled-content style=\"fixed-case\">NRG<\/jats:styled-content> even demonstrated coronal migration of the mucosal margin following <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> and needed adaptation of the provisional crown to induce soft tissue retraction. Due to <jats:styled-content style=\"fixed-case\">CTG<\/jats:styled-content> at the time of ridge preservation in the <jats:styled-content style=\"fixed-case\">RG<\/jats:styled-content>, mid\u2010facial soft tissue gain amounted to 0.9\u00a0mm at 12\u00a0months, hereby eliminating 2\/3rd of the initial recession. <jats:styled-content style=\"fixed-case\">PES<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WES<\/jats:styled-content> were favourable pointing to 10.9\/14 and 8.2\/10 respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This short\u2010term prospective study offers a proof of principle of M.I.S.I.T. in patients with a high aesthetic risk profile.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12384","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T10:56:31Z","timestamp":1425034591000},"page":"398-405","source":"Crossref","is-referenced-by-count":34,"title":["Minimally Invasive Single Implant Treatment (M.I.S.I.T.) based on ridge preservation and contour augmentation in patients with a high aesthetic risk profile: one\u2010year results"],"prefix":"10.1111","volume":"42","author":[{"given":"Jan","family":"Cosyn","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School Ghent University Ghent Belgium"},{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Pharmacy Dental Medicine Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Pollaris","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Van der Linden","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"De Bruyn","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology Faculty of Medicine and Health Sciences Dental School Ghent University Ghent Belgium"},{"name":"Department of Prosthodontics Faculty of Odontology Malm\u00f6 University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,31]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"123","article-title":"Comparison of variable\u2010thread tapered implant designs to a standard tapered implant design after immediate loading. A 3\u2010year multicentre randomised controlled trial","volume":"5","author":"Arnhart C.","year":"2012","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01234.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3182344fce"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-12-00223"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-10-00133"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080435"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080071"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513504949"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080360"},{"key":"e_1_2_5_11_1","first-page":"43","article-title":"Optimizing aesthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations","volume":"19","author":"Buser D.","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1990.010105.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100408"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12249"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00448.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01746.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2010.00300.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00417.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01888.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01921.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12403"},{"key":"e_1_2_5_22_1","first-page":"260","article-title":"Ridge preservation techniques for implant therapy","volume":"24","author":"Darby I.","year":"2009","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01235.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01398.x"},{"key":"e_1_2_5_25_1","article-title":"Ultrasonic assessment of mucosal thickness around implants: validity, reproducibility and stability of connective tissue grafts at the buccal aspect","author":"Eghbali A.","year":"2014","journal-title":"Clinical Implant Dentistry and Related Research"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01193.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00372.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02313.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(12)70029-5"},{"key":"e_1_2_5_30_1","first-page":"179","article-title":"Facial gingival tissue stability following immediate placement and provisionalization of maxillary anterior single implants: a 2\u2010 to 8\u2010year follow\u2010up","volume":"26","author":"Kan J. Y.","year":"2011","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2007.04.006"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(09)60060-3"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.3230"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01522.x"},{"key":"e_1_2_5_35_1","first-page":"578","article-title":"Single implants in the esthetic zone: analysis of recent peri\u2010implant soft tissue alterations and patient satisfaction. A photographic study","volume":"26","author":"Luo Z.","year":"2011","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02307.x"},{"key":"e_1_2_5_37_1","first-page":"9","volume-title":"ITI Treatment Guide, volume 1, Implant therapy in the esthetic zone: single\u2010tooth replacements","author":"Martin W. C.","year":"2007"},{"key":"e_1_2_5_38_1","article-title":"Bone healing after tooth extraction with or without an intervention: a systematic review of randomized controlled trials","author":"Morjaria K. R.","year":"2012","journal-title":"Clinical Implant Dentistry and Related Research"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02465.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.2560"},{"key":"e_1_2_5_42_1","first-page":"47","article-title":"Three\u2010year post\u2010loading results of a randomised, controlled, split\u2010mouth trial comparing implants with different prosthetic interfaces and design in partially posterior edentulous mandibles","volume":"7","author":"Pozzi A.","year":"2014","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01687.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(96)90346-8"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12149"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02486.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.74208"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01782.x"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02331.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02560.x"},{"key":"e_1_2_5_51_1","first-page":"59","article-title":"Are socket and ridge preservation techniques at the day of tooth extraction efficient in maintaining the tissues of the alveolar ridge?","volume":"4","author":"Weng D.","year":"2011","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_5_52_1","first-page":"27","article-title":"Connective tissue grafts for thickening peri\u2010implant tissues at implant placement. One\u2010year results from an explanatory split\u2010mouth randomised controlled clinical trial","volume":"3","author":"Wiesner G.","year":"2010","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12003"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12384","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:25:07Z","timestamp":1696274707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,31]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jcpe.12384"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12384","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,31]]}}}