{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:00:14Z","timestamp":1791295214935,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:00:00Z","timestamp":1428624000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013896","name":"BioGaia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013896","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The objective of this study was to evaluate the effects of lozenges containing\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      as an adjuvant treatment to initial periodontal therapy for chronic periodontitis patients and to detect the level of\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      colonization in the periodontal pockets of treated patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 40 patients were selected and randomly divided into two groups. Each patient had at least two teeth with one approximal site each with a probing depth (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) of 5\u20137\u00a0mm and gingival index (\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      ) of \u22652 in each quadrant. Group I received scaling and root planing (\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      ) plus\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      \u2010containing lozenges, and Group\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      received\n                      <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\n                      plus placebo. The plaque index (\n                      <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\n                      ),\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      , bleeding on probing (BoP),\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      and relative attachment level were measured. Microbiological sampling was performed at baseline and on days 21, 90, 180 and 360 and were analysed by culturing. The Bonferroni\u2010corrected paired sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, Bonferroni\u2010corrected Wilcoxon signed rank test and paired sample\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test were used to evaluate intra\u2010group differences. The Bonferroni\u2010corrected Student's\n                      <jats:italic>t\u2010<\/jats:italic>\n                      test and the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010tests were used to evaluate inter\u2010group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After treatment, the measured\n                      <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      , BoP and\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      were significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) lower in Group I compared with Group\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      at all time points. Similar observations were made for the total viable cell counts and the proportions of obligate anaerobes with the exception of day 360. In Group I, significantly fewer patients required surgery on \u22653 sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      \u2010containing lozenges may be a useful adjuvant agent to slow re\u2010colonization and improve clinical outcomes of chronic periodontitis. Further studies are required to clarify the optimal dose of the lozenges.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12387","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T02:12:55Z","timestamp":1425089575000},"page":"363-372","source":"Crossref","is-referenced-by-count":182,"title":["Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"42","author":[{"given":"Merve","family":"Tekce","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizem","family":"Ince","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hare","family":"Gursoy","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebnem","family":"Dirikan Ipci","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokser","family":"Cakar","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanju","family":"Kadir","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Microbiology Marmara University Nisantasi Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Periodontology Yeditepe University Goztepe Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422410000090"},{"key":"e_1_2_5_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"4","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2009.00989.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00157.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.00073.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01291.x"},{"key":"e_1_2_5_11_1","unstructured":"Dobrogosz J. 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