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more from the <jats:styled-content style=\"fixed-case\">ARIC<\/jats:styled-content> cohort were included. Retinal vascular diameters were measured and summarized as central retinal arteriolar\/venular equivalents (<jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content>). Periodontitis was determined by using the <jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AAP<\/jats:styled-content> definition. Multivariable linear regression models were used to estimate the relationships between <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CRVE<\/jats:styled-content> and periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No association was found between <jats:styled-content style=\"fixed-case\">CRAE<\/jats:styled-content> and periodontal status. However, <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> and severe periodontitis were positively and significantly associated. Mean <jats:styled-content style=\"fixed-case\">CRVE<\/jats:styled-content> (\u00b1SD) was 187.0\u00a0\u00b1\u00a017.2\u00a0<jats:italic>\u03bc<\/jats:italic>m in the health\u2010gingivitis group, and, respectively, 188.5\u00a0\u00b1\u00a016.3\u00a0<jats:italic>\u03bc<\/jats:italic>m (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.39) and 191.6\u00a0\u00b1\u00a016.8\u00a0<jats:italic>\u03bc<\/jats:italic>m (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) in moderate and severe periodontitis groups, after adjustment for a propensity score based on confounders. Results were consistent when analyses were restricted to participants with diabetes mellitus (<jats:italic>n<\/jats:italic>\u00a0=\u00a066), but not diabetes\u2010free subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe periodontitis is associated with larger retinal venular diameter in patients with type 2 diabetes. Further studies are needed to explore the impact of diabetes mellitus on the association between periodontitis and retinal microcirculation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12388","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T07:18:55Z","timestamp":1425107935000},"page":"342-349","source":"Crossref","is-referenced-by-count":22,"title":["Periodontitis and retinal microcirculation in the Atherosclerosis Risk in Communities study"],"prefix":"10.1111","volume":"42","author":[{"given":"Adrien","family":"Boillot","sequence":"first","affiliation":[{"name":"Department of Periodontology Rothschild Hospital (AP\u2010HP) UFR of Odontology University of Paris Diderot Paris France"},{"name":"INSERM UMS 011 Population\u2010Based Cohort Platform Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Department of Periodontology Rothschild 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