{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:54:59Z","timestamp":1778774099612,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T00:00:00Z","timestamp":1429660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sao Paulo State Research Foundation - FAPESP","award":["2009\/53934-5"],"award-info":[{"award-number":["2009\/53934-5"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A randomized controlled clinical trial was designed to evaluate the efficacy of the photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) in the treatment of residual pockets of chronic periodontitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Thirty\u2010four patients with at least four residual periodontal pockets undergoing maintenance care were included and randomly assigned to test group (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a018) or control group (sham procedure, <jats:italic>n<\/jats:italic>\u00a0=\u00a016). The intervention was performed at baseline, 3, 6 and 12\u00a0months. Clinical parameters such as pocket probing depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), bleeding on probing (BoP) and plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>) were measured before intervention and after 3, 6 and 12\u00a0months. Subgingival samples were obtained at baseline, and after 7\u00a0days, 3, 6 and 12\u00a0months to quantify <jats:italic>Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> by real\u2010time polimerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All clinical variables showed significant improvement during the study, but there was no significant difference between test and control groups. The microbiological analyses showed no differences between groups at any time during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limits of this clinical trial and considering the laser and photosensitizer protocol used, <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> failed to demonstrate additional clinical and bacteriological benefits in residual pockets treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12393","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:44:57Z","timestamp":1427219097000},"page":"440-447","source":"Crossref","is-referenced-by-count":58,"title":["Antimicrobial photodynamic effect to treat residual pockets in periodontal patients: a randomized controlled clinical trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Ver\u00f4nica F.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila V. C.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle F.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario H.","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of Sao Paulo Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario D. 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