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Serum and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> levels of resistin, adiponectin, leptin, tumour necrosis factor [<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>]\u2010<jats:italic>\u03b1<\/jats:italic> and interleukin [<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>]\u20106 were evaluated by enzyme\u2010linked immunosorbent assay at baseline, 3, 6 and 12\u00a0months post\u2010therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SRP reduced the amounts of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> in deep sites and increased the concentration of adiponectin in shallow sites of non\u2010obese patients (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> increased the concentrations of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> and leptin in patients with obesity (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic> were higher in patients with obesity than in patients without obesity at all time\u2010points (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). There were no changes in serum levels of any adipokines for any group after therapy (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). Patients with obesity exhibited higher serum levels of leptin at all time\u2010points and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 at 3\u00a0months post\u2010therapy (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity may modulate systemic and periodontal levels of adipokines in favour of pro\u2010inflammation, independently of periodontal therapy. <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> did not affect the circulating levels of adipokines in patients with or without obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12396","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T08:31:16Z","timestamp":1428481876000},"page":"431-439","source":"Crossref","is-referenced-by-count":72,"title":["Local and serum levels of adipokines in patients with obesity after periodontal therapy: one\u2010year 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