{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:57:53Z","timestamp":1788267473189,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science & Technology in Taiwan","doi-asserted-by":"crossref","award":["NSC 101 - 2314 - B - 002 - 197 - MY2"],"award-info":[{"award-number":["NSC 101 - 2314 - B - 002 - 197 - MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of the present study was to assess the cost\u2010effectiveness of various alternatives of non\u2010surgical peri\u2010implantitis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A decision analytical model was constructed and populated with parameter estimates from recent literature for reduction in pocket probing depth (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) in response to eight different treatment alternatives. A micro\u2010costing approach combined with an online expert survey was applied to simulate a decision\u2010making scenario taking place in Germany. The treatment alternatives providing the most advantageous cost\/outcome combinations were identified according to the net benefit criterion. Uncertainties regarding model input parameters were incorporated via simple and probabilistic sensitivity analysis based on Monte Carlo simulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the base case scenario, debridement alone, Air\u2010Flow\u00ae, debridement combined with PerioChip\u00ae, and debridement combined with local antibiotics were identified as treatment strategies with comparably better value for money than Er:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>laser monotherapy, Vector<jats:sup>\u2122<\/jats:sup>System, debridement combined with<jats:styled-content style=\"fixed-case\">CHX<\/jats:styled-content>, and photodynamic therapy. Sensitivity analysis revealed considerable decision uncertainty corresponding to limited evidence about different treatment alternatives for peri\u2010implantitis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Derivation of robust treatment recommendations for peri\u2010implantitis requires more comprehensive and patient\u2010centred evidence on peri\u2010implantitis treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12402","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T11:41:02Z","timestamp":1428925262000},"page":"470-477","source":"Crossref","is-referenced-by-count":28,"title":["Cost\u2010effectiveness of non\u2010surgical peri\u2010implantitis treatments"],"prefix":"10.1111","volume":"42","author":[{"given":"Stefan","family":"Listl","sequence":"first","affiliation":[{"name":"Translational Health Economics Group (THE Group) Department of Conservative Dentistry Heidelberg University Heidelberg Germany"},{"name":"Max Planck Institute for Social Law and Social Policy Munich Center for the Economics of Aging Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Fr\u00fchauf","sequence":"additional","affiliation":[{"name":"Translational Health Economics Group (THE Group) Department of Conservative Dentistry Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Dannewitz","sequence":"additional","affiliation":[{"name":"Translational Health Economics Group (THE Group) Department of Conservative Dentistry Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Weis","sequence":"additional","affiliation":[{"name":"Translational Health Economics Group (THE Group) Department of Conservative Dentistry Heidelberg University Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Kang","family":"Tu","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huei\u2010Ju","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Clovis M.","family":"Faggion","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of M\u00fcnster M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1357633X12474960"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120592"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(98)00039-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-985X.00166"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00384.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12292"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195108248.001.0001","volume-title":"Cost\u2010effectiveness in health and medicine","author":"Gold M. 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