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Ligature\u2010induced peri\u2010implantitis was initiated at 3\u00a0months post\u2010implantation. When approximately 40% of the supporting bone was lost, the ligatures were removed. The implants were subjected to the muco\u2010periosteal scaling and chlorhexidine irrigation with or without plasma irrigation. Three months later, clinical, radiographic and microbiological analyses were performed. Block biopsies were prepared for micro\u2010<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and histomorphometric analysis. The primary outcome was the difference in bone healing of peri\u2010implant sites, and the secondary outcomes included changes in clinical parameters (<jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> PD<\/jats:styled-content>) and bacterial detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, no significant differences were observed between the two groups. At 3\u00a0months post\u2010treatment, the plasma group showed a significantly higher bone level than the control group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), a significantly decreased detection of bacteria (<jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic>) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and a significant improvement in clinical examination (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limits of this study, non\u2010equilibrium plasma treatment as an adjunct to the conventional therapy is a feasible approach for the treatment of peri\u2010implantitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12403","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T11:44:51Z","timestamp":1428925491000},"page":"478-487","source":"Crossref","is-referenced-by-count":35,"title":["Effects of non\u2010equilibrium plasma in the treatment of ligature\u2010induced peri\u2010implantitis"],"prefix":"10.1111","volume":"42","author":[{"given":"Qi","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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