{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:50:55Z","timestamp":1791431455825,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Orquest, Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The goal of this study was to evaluate if a biological hydrogel of recombinant human Fibroblast Growth Factor type 2 (rh\n                      <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n                      \u20102) in a hyaluronic acid (\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      ) carrier applied in periodontal intrabony defects would enhance the clinical parameters of regeneration of the periodontal attachment apparatus\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Thirty adult patients were evaluated. Two intrabony defects present in contra\u2010lateral quadrants in each patient were randomly allocated for each of the treatment methods employed. Control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030) were treated by open debridement with the papilla preservation flaps, while the test group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030) also received a topical application of rh\n                      <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n                      \u20102\/\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      in the intrabony defect. The parameters evaluated, at baseline and after one year, were, were probing depth (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ), gingival recession (\n                      <jats:styled-content style=\"fixed-case\">REC<\/jats:styled-content>\n                      ), probing attachment level (\n                      <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>\n                      ) and probing bone level (\n                      <jats:styled-content style=\"fixed-case\">PBL<\/jats:styled-content>\n                      ). The primary outcome measures was\n                      <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>\n                      gain\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Test sites exhibited significantly more\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      reduction (5.5\n                      <jats:italic>versus<\/jats:italic>\n                      2.9\u00a0mm),\n                      <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>\n                      gains (4.8\n                      <jats:italic>versus<\/jats:italic>\n                      2.2\u00a0mm) and shallower residual\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      (4.2\n                      <jats:italic>versus<\/jats:italic>\n                      6.6\u00a0mm) than controls. Moreover, residual\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      smaller than 5\u00a0mm (100\n                      <jats:italic>versus<\/jats:italic>\n                      0%) and\n                      <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>\n                      gain &gt; 4\u00a0mm (60\n                      <jats:italic>versus<\/jats:italic>\n                      20%) was significantly more frequent in the test group\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Application of rh\n                      <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n                      \u20102\/\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      significantly improved clinical parameters of periodontal wound healing one year after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12406","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T07:29:55Z","timestamp":1430378995000},"page":"658-665","source":"Crossref","is-referenced-by-count":72,"title":["Human intrabony defect regeneration with rh\n                    <scp>FGF<\/scp>\n                    \u20102 and hyaluronic acid \u2013 a randomized controlled clinical trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Ronaldo Barcellos","family":"de Santana","sequence":"first","affiliation":[{"name":"Department of Periodontology Federal Fluminense University Dental School Niteroi Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Miller Mattos","family":"de Santana","sequence":"additional","affiliation":[{"name":"Department of Periodontology Federal Fluminense University Dental School Niteroi Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"A clinical comparison of cenobone (A Decalcified Freeze\u2010dried Bone Allograft) with autogenous bone graft in the treatment of two\u2010 and three\u2010wall intrabony periodontal defects: a human study with six\u2010month reentry","volume":"2","author":"Abolfazli N.","year":"2008","journal-title":"Journal of Dental Research, Dental Clinics, Dental Prospects"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6.65"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb17895.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_6_6_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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