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Probing parameters were assessed before and 6\u00a0months after surgery. Pain (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content><jats:sub>pain<\/jats:sub>) was self\u2010reported using a visual analogue scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content> sites and <jats:styled-content style=\"fixed-case\">DFA<\/jats:styled-content> 6 sites showed complete flap closure at 2\u00a0weeks post\u2010surgery. No significant differences in 6\u2010month changes in probing parameters and radiographic defect fill were found between groups. Significantly lower <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content><jats:sub>pain<\/jats:sub> was observed in <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content> group compared to <jats:styled-content style=\"fixed-case\">DFA<\/jats:styled-content> group at day +1, +2 and +6. A significantly greater number of analgesics were consumed in the <jats:styled-content style=\"fixed-case\">DFA<\/jats:styled-content> group compared to the <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content> group at day +1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When combined with rh<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content> and <jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TCP<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">SFA<\/jats:styled-content> may result in similar clinical outcomes, better quality of early wound healing, and lower pain and consumption of analgesics during the first postoperative days compared to the <jats:styled-content style=\"fixed-case\">DFA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12409","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T14:35:05Z","timestamp":1430231705000},"page":"557-566","source":"Crossref","is-referenced-by-count":49,"title":["Single <i>versus<\/i> double flap approach in periodontal regenerative treatment"],"prefix":"10.1111","volume":"42","author":[{"given":"Gian Pietro","family":"Schincaglia","sequence":"first","affiliation":[{"name":"Division of Periodontology School of Dental Medicine University of Connecticut Health Center Farmington CT USA"},{"name":"Research Center for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hebert","sequence":"additional","affiliation":[{"name":"Division of Periodontology School of Dental Medicine University of Connecticut Health Center Farmington CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-7809","authenticated-orcid":false,"given":"Roberto","family":"Farina","sequence":"additional","affiliation":[{"name":"Research Center for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Research Center for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[{"name":"Research Center for the Study of Periodontal and Peri\u2010Implant Diseases University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"213","article-title":"Periodontal regeneration in human Class II furcations using purified recombinant human platelet\u2010derived growth factor\u2010BB (rhPDGF\u2010BB) with bone allograft","volume":"23","author":"Camelo M.","year":"2003","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_7_4_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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