{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:08:10Z","timestamp":1783714090022,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:00:00Z","timestamp":1432944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangdong Province","award":["C1030270"],"award-info":[{"award-number":["C1030270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Scientific evidence on the effects of chronic periodontitis on end\u2010stage renal disease (<jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content>) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non\u2010surgical periodontal therapy on the clinical response and systemic status of <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients in the intervention group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>48) received non\u2010surgical periodontal therapy and then a supragingival prophylaxis at the 3\u2010month follow up, and those in the control group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>49) received no intervention throughout the study. At 6\u00a0weeks, 3\u00a0months, and 6\u00a0months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed a significant improvement in clinical\u00a0periodontal\u00a0parameters (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) in the intervention group. Compared to the control group, the intervention group had significantly lower high\u2010sensitivity C\u2010reactive protein at 3\u00a0months and 6\u00a0months. Significant improvements were found (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) in interleukin\u20106, ferritin, albumin, creatinine, blood urea nitrogen, and transferrin after therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> patients. Non\u2010surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in <jats:styled-content style=\"fixed-case\">ESRD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12411","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T11:29:48Z","timestamp":1430393388000},"page":"537-546","source":"Crossref","is-referenced-by-count":69,"title":["The clinical response and systemic effects of non\u2010surgical periodontal therapy in end\u2010stage renal disease patients: a 6\u2010month randomized controlled clinical trial"],"prefix":"10.1111","volume":"42","author":[{"given":"Fuchun","family":"Fang","sequence":"first","affiliation":[{"name":"College of Stomatology Southern Medical University Guangzhou China"},{"name":"Department of Stomatology Nanfang Hospital Southern Medical University Guangzhou 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