{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:55:37Z","timestamp":1791888937822,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH\/NIDCR","award":["DE019872"],"award-info":[{"award-number":["DE019872"]}]},{"name":"Michigan Center for Oral Health Research"},{"name":"Talentia Scholarship Program"},{"name":"Andalusian Knowledge Agency"},{"name":"European Union's Seventh Framework Program, Marie Sk\u0142odowska-Curie actions"},{"name":"COFUND","award":["291780"],"award-info":[{"award-number":["291780"]}]},{"name":"Regional Ministry of Economy, Innovation, Science and Employment, Junta de Andaluc\u00eda"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tissue repair and regeneration is assisted by the efficient coordination of cell and extracellular matrix interactions mediated by matricellular molecules such as periostin. Given its high expression around the teeth, the periodontal organ represents an ideal system to capture the protein dynamics during wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational prospective case\u2013control study was designed to characterize periostin changes over time after periodontal surgery in tissue, oral fluids and serum by histological, protein and <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histological analysis showed lower periostin with a diffuse local distribution pattern in disease patients. Levels of periostin in gingival crevicular\u00a0fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) increased over time for both groups, more noticeably in\u00a0the periodontitis subjects. A transient and subtle change in circulating periostin levels was also noticed. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> periostin levels contrasted with the protein levels and may indicate the underlying post\u2010transcriptional regulatory process during chronic inflammation. Levels of known periodontal\u00a0disease biomarkers such as <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u2010\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1\u2010\u03b1, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101\u03b1 and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> served as tissue stability markers and complemented the clinical parameters recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The transient local increase in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> periostin after eliminating the\u00a0local etiology in periodontally affected sites suggests its importance in the maturation and stability of the connective tissue. The decreasing levels\u00a0observed as the tissue healed highlight its spatial\/temporal significance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12432","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T06:16:55Z","timestamp":1437632215000},"page":"764-772","source":"Crossref","is-referenced-by-count":29,"title":["Preliminary insight into the periostin leverage during periodontal tissue healing"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-1341","authenticated-orcid":false,"given":"Miguel","family":"Padial\u2010Molina","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"},{"name":"Department of Oral Surgery and Implant Dentistry School of Dentistry University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Volk","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector F.","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/JCM.S5899"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12254"},{"key":"e_1_2_7_4_1","first-page":"821","article-title":"Circulating levels of periostin may help identify patients with more aggressive colorectal cancer","volume":"34","author":"Ben Q. 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