{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:39:41Z","timestamp":1760783981027},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,29]],"date-time":"2015-08-29T00:00:00Z","timestamp":1440806400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Finnish Dental Society Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the association between periodontitis and serum parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) and the response of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> to periodontal therapy in type 1 diabetic patients (T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>). We also investigated the <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\u20101,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D axis in the T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Periodontal health status was recorded in 54 periodontitis patients and 30 periodontally healthy controls (case\u2013control data). Data were also collected from patients with type 1 diabetes mellitus at the baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a076) and after periodontal therapy (intervention data) (<jats:italic>n<\/jats:italic>\u00a0=\u00a053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontitis was not associated with serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> in the case\u2013control data or at the baseline of the intervention data. A post\u2010therapy increase in serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was found in 61% of the T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients; in patients with moderate or severe periodontitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a026) the average increase was 0.6\u00a0pmol\/l (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) and in patients with no or mild periodontitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a027) 0.2\u00a0pmol\/l (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.250). In 47% of the T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients, an increase in <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> was associated with an increase in serum 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An association between serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> and periodontal infection was found only after periodontal therapy in T1<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients. This post\u2010treatment response in serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> may partly explain the previously reported increase in serum 1,25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:sub>2<\/jats:sub>D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12436","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T13:35:29Z","timestamp":1437831329000},"page":"726-732","source":"Crossref","is-referenced-by-count":9,"title":["Serum parathyroid hormone and\u00a0active vitamin D in chronic periodontitis"],"prefix":"10.1111","volume":"42","author":[{"given":"Georgios N.","family":"Antonoglou","sequence":"first","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Research Group of Oral Health Sciences University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Knuuttila","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Research Group of Oral Health Sciences University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onni","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Medical Research Unit Sein\u00e4joki Central Hospital and University of Tampere Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Research Group of Oral Health Sciences University of Oulu Oulu Finland"},{"name":"Insitute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Surgery Kuopio University Hospital Kuopio Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Raunio","sequence":"additional","affiliation":[{"name":"Specialist Dental Health Care Unit City of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liisa","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Oulu Health Care Center Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riitta","family":"Karttunen","sequence":"additional","affiliation":[{"name":"Institute of Diagnostics Department of Medical Microbiology and Immunology University of Oulu Oulu Finland"},{"name":"Department of Bacteriology and Immunology Haartman Institute Laboratory Division (HUSLAB) Helsinki University Central Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tellervo","family":"Tervonen","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Geriatric Dentistry Research Group of Oral Health Sciences University of Oulu Oulu Finland"},{"name":"Medical Research Center Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.07s214"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050082"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2007.00211.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1906"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12207"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3846"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308201006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005361"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010061"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01578.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2010.00739.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110586"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-2275(20)38950-1","article-title":"Biologically active metabolite of vitamin D3 from bone, liver, and blood serum","volume":"7","author":"Lund J.","year":"1966","journal-title":"Journal of Lipid Research"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.7.1057"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900416"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22969"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.141098"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01343.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01386.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130155"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90186-Z"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:10:18Z","timestamp":1696219818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jcpe.12436"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12436","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}