{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:56:41Z","timestamp":1784044601310,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2013-062881"],"award-info":[{"award-number":["2013-062881"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NRF"},{"name":"Oromaxillofacial Dysfunction Research Center for the Elderly","award":["2014-050477"],"award-info":[{"award-number":["2014-050477"]}]},{"name":"Seoul National University in Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to locate the genes related to periodontitis through genome\u2010wide association study (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>) in Korean population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total of 677 adults aged 44\u201388\u00a0years were recruited from the Yangpyeong cohort in Korea. The participants did not have self\u2010reported metabolic diseases, cardiovascular diseases or cancer. Periodontitis was assessed using alveolar bone loss from a digital panoramic radiograph and classified into three groups: normal to mild, moderate and severe periodontitis. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> from blood samples were genotyped using the Illumina Human 1M\u2010duo Beadchip. Multivariable logistic regression analysis in <jats:styled-content style=\"fixed-case\">PLINK<\/jats:styled-content> was applied to examine the single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) related to periodontitis after controlling for various confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Associations of three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s suggested <jats:italic><jats:styled-content style=\"fixed-case\">TENM<\/jats:styled-content>2<\/jats:italic> (rs4242220) and <jats:italic><jats:styled-content style=\"fixed-case\">LDLRAD<\/jats:styled-content>4<\/jats:italic> (rs12969041, rs2027756) as putative risk genes of chronic periodontitis (<jats:italic>p<\/jats:italic>\u2010values &lt;1\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>). The odds ratio [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)] of <jats:italic><jats:styled-content style=\"fixed-case\">TENM<\/jats:styled-content>2<\/jats:italic> was 0.53 (0.40\u20130.70) for moderate periodontitis and that of <jats:italic><jats:styled-content style=\"fixed-case\">LDLRAD<\/jats:styled-content>4<\/jats:italic> was 2.86 (1.92\u20134.27) for severe periodontitis. Two nonsynonymous <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of protein coding region and seven <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s selected from previous reports showed nominal association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our <jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content> supports a previously reported gene of <jats:italic><jats:styled-content style=\"fixed-case\">TENM<\/jats:styled-content>2<\/jats:italic> and newly suggests <jats:italic><jats:styled-content style=\"fixed-case\">LDLRAD<\/jats:styled-content>4<\/jats:italic>. These two genes\u2019 role on lipid metabolism may play a part in the molecular aetiology of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12437","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T13:38:48Z","timestamp":1437831528000},"page":"703-710","source":"Crossref","is-referenced-by-count":56,"title":["Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort"],"prefix":"10.1111","volume":"42","author":[{"given":"Kyung\u2010Won","family":"Hong","sequence":"first","affiliation":[{"name":"Theragen Etex Bio Institute Suwonsi Gyeonggi\u2010do Korea"},{"name":"Division of Biomedical Informatics Center for Genome Science National Institute of Health KCDC Cheongju\u2010si Chungbuk Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Seop","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Dentistry 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