{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:45:07Z","timestamp":1788396307990,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinic for Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Switzerland"},{"name":"VITA Zahnfabrik H. Rauter GmbH & Co. KG, Bad S\u00e4ckingen, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess whether or not peri\u2010implant soft tissue dimensions and hard tissue integration of loaded zirconia implants are similar to those of a titanium implant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In six dogs, two one\u2010piece zirconia implants (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ZD<\/jats:styled-content>), a two\u2010piece zirconia implant (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>) and a control one\u2010piece titanium implant (<jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content>) were randomly placed. <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content> crowns were cemented at 6\u00a0months. Six months later, animals were killed and histomorphometric analyses were performed, including: the level of the mucosal margin, the extent of the peri\u2010implant mucosa, the marginal bone loss and the bone\u2010to\u2010implant contact (<jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content>). Means of outcomes variables were calculated together with their corresponding 95% confidence intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In general, the mucosal margin was located coronally to the implant shoulder. The buccal peri\u2010implant mucosa ranged between 2.64\u00a0\u00b1\u00a00.70\u00a0mm (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>) and 3.03\u00a0\u00b1\u00a01.71\u00a0mm (<jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>) (for all median comparisons <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The relative marginal bone loss ranged between 0.65\u00a0\u00b1\u00a00.61\u00a0mm (<jats:styled-content style=\"fixed-case\">BPI<\/jats:styled-content>) and 1.73\u00a0\u00b1\u00a01.68\u00a0mm (<jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>) (buccal side), and between 0.55\u00a0\u00b1\u00a00.37\u00a0mm (<jats:styled-content style=\"fixed-case\">VC<\/jats:styled-content>) and 1.69\u00a0\u00b1\u00a01.56\u00a0mm (<jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>) (lingual side) (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The mean <jats:styled-content style=\"fixed-case\">BIC<\/jats:styled-content> ranged between 78.6%\u00a0\u00b1\u00a017.3% (<jats:styled-content style=\"fixed-case\">ZD<\/jats:styled-content>) and 87.9%\u00a0\u00b1\u00a013.6% (<jats:styled-content style=\"fixed-case\">STM<\/jats:styled-content>) without statistically significant differences between the groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One\u2010 and two\u2010piece zirconia rendered similar peri\u2010implant soft tissue dimensions and osseointegration compared to titanium implants that were placed at 6\u00a0months of loading. Zirconia implants, however, exhibited a relatively high fracture rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12453","type":"journal-article","created":{"date-parts":[[2015,9,12]],"date-time":"2015-09-12T05:46:27Z","timestamp":1442036787000},"page":"967-975","source":"Crossref","is-referenced-by-count":45,"title":["Histological analysis of loaded zirconia and titanium dental implants: an experimental study in the dog mandible"],"prefix":"10.1111","volume":"42","author":[{"given":"Daniel S.","family":"Thoma","sequence":"first","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran I.","family":"Benic","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1526","authenticated-orcid":false,"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Kohal","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Albert\u2010Ludwigs\u2010University Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Sanz Martin","sequence":"additional","affiliation":[{"name":"Universidad Complutense Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Gonz\u00e1lez","family":"Cantalapiedra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. 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