{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:51:15Z","timestamp":1760889075421},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the amount of the mineralization of a bovine bone substitute material in sinus floor augmentation after healing times of 3 and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Fifty\u2010one patients were randomized into two healing time groups and received sinus floor augmentations with a bovine bone material. After 3 or 6\u00a0months of healing, trephine bone biopsies were retrieved. The biopsies were processed for histological and histomorphometric evaluations to primarily investigate the amount of mineralized bone in the augmented area and secondarily compare the amount of mineralized bone in the augmented area and in the pristine bone. Statistical tests were performed to analyse the fraction of the mineralized bone (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The biopsies of both groups showed remnants of the well\u2010integrated bone substitute material. The histology revealed osteoblasts, osteocytes with osteoid, and osteoclasts. The mean percentage of mineralized bone in the augmented area was 23.8% (3\u00a0months group) and 23.6% (6\u00a0months group; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.9246); the amount of remaining bone substitute material was 35% (3\u00a0months group) and 33.9% (6\u00a0months group; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.6325).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It can be concluded that the bone maturation in the augmented sinus using the bovine bone material is similar after 3 and 6\u00a0months. Thus, implant installation after 3\u00a0months following a lateral window sinus floor augmentation approach using a bovine bone material seems to be clinically acceptable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12466","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T08:46:45Z","timestamp":1444034805000},"page":"1052-1059","source":"Crossref","is-referenced-by-count":11,"title":["Effect of two different healing times on the mineralization of newly formed bone using a bovine bone substitute in sinus floor augmentation: a randomized, controlled, clinical and histological investigation"],"prefix":"10.1111","volume":"42","author":[{"given":"Ralf Joachim","family":"Kohal","sequence":"first","affiliation":[{"name":"Department of Prosthetic Dentistry Center for Dental Medicine \u00a0Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Gubik","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Orofacial Orthopedics Center for Dental, Oral and Maxillary Medicine University of Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Strohl","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Center for Dental Medicine Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Stampf","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Department of Clinical Research University Hospital Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"B\u00e4chle","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry Center for Dental Medicine \u00a0Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Alexander","family":"Hurrle","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry Center for Dental Medicine \u00a0Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian Berthold Maximilian","family":"Patzelt","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry Center for Dental Medicine \u00a0Medical Center \u2013 University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00642.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.10.031"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00656.x"},{"key":"e_1_2_6_5_1","first-page":"395","article-title":"Efficacy of porous bovine bone mineral in various types of osseous deficiencies: clinical observations and literature review","volume":"21","author":"Artzi Z.","year":"2001","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.01.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2010.10.017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01498.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90185-3"},{"key":"e_1_2_6_10_1","first-page":"613","article-title":"Grafting of the maxillary sinus floor with autogenous marrow and bone","volume":"38","author":"Boyne P. J.","year":"1980","journal-title":"Journal of Oral Surgery"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2007.00050.x"},{"key":"e_1_2_6_12_1","first-page":"1317","article-title":"Sinus augmentation with bovine hydroxyapatite\/synthetic peptide in a sodium hyaluronate carrier (PepGen P\u201015 Putty): a clinical investigation of different healing times","volume":"26","author":"Butz F.","year":"2011","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.11.023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01357.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01565.x"},{"key":"e_1_2_6_16_1","first-page":"565","article-title":"Systematic review of survival rates for implants placed in the grafted maxillary sinus","volume":"24","author":"Fabbro M.","year":"2004","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1982.tb00172.x"},{"key":"e_1_2_6_18_1","first-page":"7","article-title":"Effectiveness of sinus lift procedures for dental implant rehabilitation: a Cochrane systematic review","volume":"3","author":"Esposito M.","year":"2010","journal-title":"European Journal of Oral Implantology"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090263"},{"key":"e_1_2_6_20_1","first-page":"273","article-title":"Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6\u2010 to 8\u2010month postsurgical assessment of vital bone formation. A pilot study","volume":"28","author":"Froum S. J.","year":"2008","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_21_1","first-page":"543","article-title":"Comparison of mineralized cancellous bone allograft (Puros) and anorganic bovine bone matrix (Bio\u2010Oss) for sinus augmentation: histomorphometry at 26 to 32\u00a0weeks after grafting","volume":"26","author":"Froum S. J.","year":"2006","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_22_1","first-page":"361","article-title":"GBR using bovine bone matrix and resorbable and nonresorbable membranes. Part 1: histologic results","volume":"23","author":"Fugazzotto P. A.","year":"2003","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_23_1","first-page":"146","article-title":"Komplikationen an den Entnahmestellen autologer Spongiosatransplantate","volume":"12","author":"Gerngross H.","year":"1982","journal-title":"Aktuelle Traumatol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012002135.x"},{"key":"e_1_2_6_25_1","first-page":"635","article-title":"A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture","volume":"17","author":"Hallman M.","year":"2002","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-5-12"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1997.080606.x"},{"key":"e_1_2_6_28_1","first-page":"11","article-title":"Report of the Sinus Consensus Conference of 1996","volume":"13","author":"Jensen O. T.","year":"1998","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_29_1","first-page":"199","article-title":"Histomorphometric analysis of natural bone mineral for maxillary sinus augmentation","volume":"19","author":"John H. D.","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2010.0035"},{"key":"e_1_2_6_31_1","first-page":"598","article-title":"One\u2010step approach for implant placement and subantral bone regeneration using bovine hydroxyapatite: a 2\u2010 to 6\u2010year follow\u2010up study","volume":"25","author":"Lambert F.","year":"2010","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02239.x"},{"key":"e_1_2_6_33_1","first-page":"471","article-title":"Bone reaction to bovine hydroxyapatite for maxillary sinus floor augmentation: histologic results in humans","volume":"26","author":"Lee Y. M.","year":"2006","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.11.023"},{"key":"e_1_2_6_35_1","first-page":"490","article-title":"Moglichkeiten und Grenzen der Implantologie beim alteren Patienten","volume":"44","author":"Neukam F. W.","year":"1989","journal-title":"Dtsch Zahnarztl Z"},{"key":"e_1_2_6_36_1","first-page":"143","article-title":"Studies on the state of pneumatization of the sinus maxillaris","volume":"138","author":"Nowak R.","year":"1975","journal-title":"Annals of Anatomy"},{"key":"e_1_2_6_37_1","first-page":"835","article-title":"Bone reactions to anorganic bovine bone (Bio\u2010Oss) used in sinus augmentation procedures: a histologic long\u2010term report of 20 cases in humans","volume":"14","author":"Piattelli M.","year":"1999","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.07.036"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01699.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-11-00160"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140316.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000220120.54308.f3"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1055\/b-0034-52980"},{"key":"e_1_2_6_44_1","first-page":"935","article-title":"Deproteinized bovine bone versus beta\u2010tricalcium phosphate in sinus augmentation surgery: a comparative histologic and histomorphometric study","volume":"23","author":"Simunek A.","year":"2008","journal-title":"International Journal of Oral Maxillofacial Implants"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2003.140211.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-004-0530-3"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2000.011004334.x"},{"key":"e_1_2_6_48_1","first-page":"9","article-title":"Repair of large sinus membrane perforations using stabilized collagen barrier membranes: surgical techniques with histologic and radiographic evidence of success","volume":"28","author":"Testori T.","year":"2008","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01661.x"},{"key":"e_1_2_6_50_1","first-page":"556","article-title":"Maxillary sinus grafting with anorganic bovine bone: a clinical report of long\u2010term results","volume":"18","author":"Valentini P.","year":"2003","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_51_1","first-page":"245","article-title":"Sinus grafting with porous bone mineral (Bio\u2010Oss) for implant placement: a 5\u2010year study on 15 patients","volume":"20","author":"Valentini P.","year":"2000","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_52_1","first-page":"551","article-title":"Sinus augmentation utilizing anorganic bovine bone (Bio\u2010Oss) with absorbable and nonabsorbable membranes placed over the lateral window: histomorphometric and clinical analyses","volume":"25","author":"Wallace S. S.","year":"2005","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_53_1","first-page":"413","article-title":"Schneiderian membrane perforation rate during sinus elevation using piezosurgery: clinical results of 100 consecutive cases","volume":"27","author":"Wallace S. S.","year":"2007","journal-title":"International Journal of Periodontics and Restorative Dentistry"},{"key":"e_1_2_6_54_1","first-page":"209","article-title":"Grafting of the maxillary sinus with intraorally harvested autogenous bone prior to implant placement","volume":"3","author":"Wood R. M.","year":"1988","journal-title":"International Journal of Oral and Maxillofacial Implants"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2000.011003217.x"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:09:21Z","timestamp":1696280961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jcpe.12466"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12466","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}