{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:17:52Z","timestamp":1782494272103,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Queen Elizabeth Hospital Charities"},{"name":"European Community's Collaborative project","award":["FP7-HEALTH-2010-261460"],"award-info":[{"award-number":["FP7-HEALTH-2010-261460"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aims of this study were as follows: (i) To assess the prevalence of periodontitis among patients with primary Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>) and comparator groups of patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) and osteoarthritis (<jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content>). (ii) To perform a pilot study to compare serum antibody responses to 10 oral\/periodontal bacteria in these patient groups and a historical comparator group of patients with periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Standard clinical periodontal assessments were performed on 39 <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>, 36 <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> and 23 <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> patients and \u201cIn\u2010house\u201d antibody <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>s for serum antibodies against 10 oral\/periodontal bacteria were performed in these groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six percent of the <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> group, 64% of the <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> group and 48% of the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> group had moderate\/severe periodontitis. These frequencies did not reach statistical significance between groups. Raised antibody levels to <jats:italic>Prevotella denticola<\/jats:italic> were found in the <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RA<\/jats:styled-content> and periodontitis groups compared to the <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> group. Significant between group differences were seen for <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>,<jats:italic> Prevotella intermedia<\/jats:italic> and <jats:italic>Campylobacter showae<\/jats:italic>. None of these differences were specifically associated with <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed no increase in periodontitis in <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> patients. Although the <jats:italic>P.\u00a0denticola<\/jats:italic> data are of interest, identifying bacterial triggering factors for <jats:styled-content style=\"fixed-case\">pSS<\/jats:styled-content> will likely require alternative strategies including modern techniques such as microbiome analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12485","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T05:43:06Z","timestamp":1449639786000},"page":"26-33","source":"Crossref","is-referenced-by-count":31,"title":["Periodontitis prevalence and serum antibody reactivity to periodontal bacteria in primary Sj\u00f6gren's syndrome: a pilot study"],"prefix":"10.1111","volume":"43","author":[{"given":"Bozo","family":"Lugonja","sequence":"first","affiliation":[{"name":"School of Immunity &amp; Infection University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Yeo","sequence":"additional","affiliation":[{"name":"School of Immunity &amp; Infection University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Milward","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dietrich","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain L. 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