{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:15Z","timestamp":1771550715719,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,23]],"date-time":"2016-01-23T00:00:00Z","timestamp":1453507200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008364","name":"Tandl\u00e6geforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["F\u20102009\u2010SUN\u20101\u201057"],"award-info":[{"award-number":["F\u20102009\u2010SUN\u20101\u201057"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To perform a cross\u2010sectional study on the carrier frequency of <jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 and non\u2010<jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotypes of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> in Moroccan school children and relate the presence of these genotypes to the periodontal status in the mixed dentition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A plaque sample from 513 children was analysed by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.\u00a0<jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype\u2010positive subjects (<jats:italic>n<\/jats:italic>\u00a0=\u00a046), an equally sized group of non\u2010<jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype\u2010positive subjects, and an <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>\u2010negative group were randomly chosen among the remaining subjects for clinical and radiographic examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 513 children, 46 (9.0%) carried the <jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype and 186 (36.3%) were positive for non\u2010<jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotypes<jats:italic>,<\/jats:italic> whereas <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> could not be detected in the remaining 281 subjects. Among 75 subjects with mixed dentition and selected for clinical examination, clinical attachment loss (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) \u22653\u00a0mm at two or more periodontal sites on primary teeth was found in the <jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype\u2010positive group only. In total, 6.7% of subjects with primary teeth present showed <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> \u22653\u00a0mm at two or more sites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The carrier frequency of the <jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic> was at a comparable level to frequencies previously found in Moroccan adolescent populations. Clinical attachment loss, manifesting already in the primary dentition, was found only in the group of Moroccan children carrying the <jats:styled-content style=\"fixed-case\">JP<\/jats:styled-content>2 genotype of <jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12486","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T12:53:00Z","timestamp":1449751980000},"page":"19-25","source":"Crossref","is-referenced-by-count":14,"title":["The <scp>JP<\/scp>2 genotype of <i>Aggregatibacter actinomycetemcomitans<\/i> and marginal periodontitis in the mixed dentition"],"prefix":"10.1111","volume":"43","author":[{"given":"Anne Birkeholm","family":"Jensen","sequence":"first","affiliation":[{"name":"Section for Pediatric Dentistry Department of Dentistry, Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oum Keltoum","family":"Ennibi","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Medicine Dentistry Mohammed V Souissi University Rabat Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zouheir","family":"Ismaili","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Medicine Dentistry Mohammed V Souissi University Rabat Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte","family":"Haubek","sequence":"additional","affiliation":[{"name":"Section for Pediatric Dentistry Department of Dentistry, Health Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01006.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.8.682"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00564.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00200.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(81)90164-3"},{"key":"e_1_2_6_8_1","first-page":"199","article-title":"Radiographic assessment of the alveolar bone in children and adolescents","volume":"10","author":"Bimstein E.","year":"1988","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00406.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.2.501-508.1994"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.998"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.9.761"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00777.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00338-09"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00767.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.642002"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00189.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00653-07"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00161.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411010120020201"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.912"},{"key":"e_1_2_6_22_1","first-page":"3037","article-title":"Racial tropism of a highly toxic clone of Actinobacillus actinomycetemcomitans with juvenile periodontitis","volume":"35","author":"Haubek D.","year":"1997","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301006"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60135-X"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800062001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2006.00735.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v6.23980"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01734-06"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/jcm.34.6.1576-1578.1996","article-title":"Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin","volume":"34","author":"Haubek D.","year":"1996","journal-title":"Journal of Clinical Microbiology"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2004.00518.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104095"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12209"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110699"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01457.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035002085.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00709.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.10.4829-4832.2003"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00610.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512456039"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00137.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01625.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb01717.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00719.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb01756.x"},{"key":"e_1_2_6_45_1","first-page":"58","article-title":"Biochemical and morphological characterization of the killing of human monocytes by leukotoxin derived from Actinobacillus actinomycetemcomitans","volume":"28","author":"Taichmann N. S.","year":"1980","journal-title":"Infection and Immunity"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb02231.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.12.707"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12486","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T12:37:00Z","timestamp":1695991020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jcpe.12486"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12486","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}