{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:04:19Z","timestamp":1766048659220,"version":"3.37.3"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the efficacy of a desensitizing regimen compared to a control in preventing the occurrence and\/or alleviating dentin\/root sensitivity (<jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content>) following non\u2010surgical (<jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content>) and surgical periodontal treatment (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010four chronic\u2010periodontitis patients (<jats:styled-content style=\"fixed-case\">CPP<\/jats:styled-content>) were randomized into a test group (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) using an in\u2010office prophylaxis paste and a toothpaste at home both containing 8% arginine and calcium carbonate (Pro\u2010Argin<jats:sup>\u2122<\/jats:sup> Technology) or into a control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a036) receiving a fluoride\u2010free prophylaxis paste and a fluoride toothpaste. The examiner applied the assigned paste onto selected teeth for 3 s following <jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content> and for 60\u00a0s before flap closure. Patients brushed with the assigned toothpaste twice daily throughout the study. <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content> to air stimulus was assessed by the Schiff scale (0\u20133) and the Visual Analog Scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>: 0\u2013100\u00a0mm) six times over 17 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the test group, <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores significantly decreased at 8, 11 and 17 weeks from baseline (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.003) and Schiff scores at 8 and 11 weeks from baseline (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.014). The control group exhibited significant increases in <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> and Schiff during the study period (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.006). Marked inter\u2010group differences were noted at all time points (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined use of desensitizing products (8% arginine and calcium carbonate) in\u2010office and at\u2010home prevented <jats:styled-content style=\"fixed-case\">DRS<\/jats:styled-content> development and maintained this effect for 17 weeks following <jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12490","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T15:09:14Z","timestamp":1449932954000},"page":"138-146","source":"Crossref","is-referenced-by-count":6,"title":["Control of dentin\/root sensitivity during non\u2010surgical and surgical periodontal treatment"],"prefix":"10.1111","volume":"43","author":[{"given":"Nantin Panagiota","family":"Giassin","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-9532","authenticated-orcid":false,"given":"Danae Anastasia","family":"Apatzidou","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Solomou","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis R.","family":"Mateo","sequence":"additional","affiliation":[{"name":"LRM Statistical Consulting Hoboken NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotinos S.","family":"Panagakos","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Co. Pistaway NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Periodontology and Implant Biology Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-595X.2002.tb00936.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01284.x"},{"key":"e_1_2_7_4_1","first-page":"e14","article-title":"Incidence and time course of dentinal hypersensitivity after periodontal surgery","volume":"58","author":"Al\u2010Sabbagh M.","year":"2010","journal-title":"General Dentistry"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-8-200104170-00012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00243.x"},{"key":"e_1_2_7_7_1","first-page":"115","article-title":"Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450\u00a0ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450\u00a0ppm fluoride, and to a control toothpaste with 1450\u00a0ppm fluoride: a three\u2010day clinical study in Mississauga, Canada","volume":"20","author":"Ayad F.","year":"2009","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_7_8_1","first-page":"10","article-title":"Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450\u00a0ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight\u2010week clinical study on Canadian adults","volume":"20","author":"Ayad F.","year":"2009","journal-title":"The Journal of Clinical Dentistry"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2006.tb00431.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1963.0104"},{"key":"e_1_2_7_11_1","first-page":"221","article-title":"Consensus\u2010based recommendations for the diagnosis and management of dentin hypersensitivity","volume":"69","author":"Canadian Advisory Board on Dentin Hypersensitivity","year":"2003","journal-title":"Journal (Canadian Dental Association)"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00525.x"},{"issue":"2","key":"e_1_2_7_13_1","first-page":"6","article-title":"Clinical significance of non\u2010surgical periodontal therapy: an evidence\u2010based perspective of scaling and root planing","volume":"29","author":"Cobb C. 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