{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T23:27:45Z","timestamp":1773962865001,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003409","name":"GABA International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine the prospective association between sex steroid concentrations with periodontal progression and incident tooth loss in men and women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 1465 women and 1838 men (age 20\u201381\u00a0years) with completed five\u2010year\u2010follow\u2010up from the Study\u2010of\u2010Health\u2010in\u2010Pomerania, a population\u2010based longitudinal cohort. Serum levels of total testosterone (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>) and other sex steroids were measured. Mean clinical attachment loss (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) and the number of teeth were assessed. Generalized regression models were implemented for cross\u2010sectional and longitudinal analyses, adjusting for age, education, smoking, waist circumference, diabetes, physical activity, blood sampling time and time between baseline and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fully adjusted models revealed no consistent associations between<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>and mean<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>, neither in cross\u2010sectional [men: \u00df\u00a0=\u00a0\u22120.0004 (\u22120.023;0.022),<jats:italic>p<\/jats:italic>\u00a0=\u00a00.97; women: \u00df\u00a0=\u00a0\u22120.033 (\u22120.057; \u22120.009),<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006] nor in longitudinal analyses [men: \u00df\u00a0=\u00a0\u22120.033 (\u22120.100;0.034),<jats:italic>p<\/jats:italic>\u00a0=\u00a00.33; women: \u00df\u00a0=\u00a0\u22120.023 (\u22120.086;0.040),<jats:italic>p<\/jats:italic>\u00a0=\u00a00.47]. For tooth loss, neither cross\u2010sectional nor longitudinal associations with any of the sex steroid concentrations were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No consistent associations of sexual steroids with periodontal progression or tooth loss were found. Further cohort studies are necessary to evaluate possible associations between endocrinological parameters, like supra\u2010 or subphysiologic testosterone concentrations, and periodontal progression or tooth loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12493","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T13:14:45Z","timestamp":1450012485000},"page":"10-18","source":"Crossref","is-referenced-by-count":6,"title":["Prospective association of sex steroid concentrations with periodontal progression and incident tooth loss"],"prefix":"10.1111","volume":"43","author":[{"given":"Stefanie","family":"Samietz","sequence":"first","affiliation":[{"name":"Policlinic of Prosthetic Dentistry, Gerodontology and Biomaterials Center of Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birte","family":"Holtfreter","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Endodontology Periodontology and Pediatric Dentistry Center of Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Mundt","sequence":"additional","affiliation":[{"name":"Policlinic of Prosthetic Dentistry, Gerodontology and Biomaterials Center of Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institute of Community Medicine Section\u00a0Epidemiology of Health Care and Community Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"V\u00f6lzke","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine SHIP\/Clinical\u2010Epidemiological Research University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Nauck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kocher","sequence":"additional","affiliation":[{"name":"Unit of Periodontology Department of Restorative Dentistry, Endodontology Periodontology and Pediatric Dentistry Center of Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner","family":"Biffar","sequence":"additional","affiliation":[{"name":"Policlinic of Prosthetic Dentistry, Gerodontology and Biomaterials Center of Oral Health University Medicine Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"3528","article-title":"Inflammatory and bone turnover markers in relation to PTH and vitamin D status among saudi postmenopausal women with and without osteoporosis","volume":"7","author":"Al\u2010Daghri N. M.","year":"2014","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2006.00252.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117995"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq158"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050286"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6879.688"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.11.1288"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0173"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(84)90023-4"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.108.005561"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-089X(92)90017-B"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01849.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0267-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2134"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.2.7219"},{"key":"e_1_2_5_17_1","first-page":"370","article-title":"Study of Health in Pomerania (SHIP): a health survey in an East German region. Objectives and design of the oral health section","volume":"34","author":"Hensel E.","year":"2003","journal-title":"Quintessence International"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01941.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01361.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2125"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01324255"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0954-6820.1988.tb05563.x","article-title":"The cardiovascular risk factor profile in the study area Augsburg. Results from the first MONICA survey 1984\/85","volume":"728","author":"Keil U.","year":"1988","journal-title":"Acta Medica Scandinavica. Supplementum"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7736"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00899-3"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2007.07.004"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.2.M76"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.03206.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060110"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080518"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1830"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.11.1962"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509341013"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/28.5.964"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12352"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041943"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0307"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.53.333"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0303-6979.2003.00428.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00302.x"},{"key":"e_1_2_5_41_1","volume-title":"Stata statistical software: release 12.1","author":"StataCorp.","year":"2012"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2033"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.105841"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00131-8"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0003"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp394"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2116"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12493","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:16:25Z","timestamp":1718241385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jcpe.12493"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12493","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}