{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:30:42Z","timestamp":1768717842891,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"State of Sao Paulo Research Foundation","award":["2010\/07326-0"],"award-info":[{"award-number":["2010\/07326-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This double\u2010blind, placebo\u2010controlled clinical study compared multiple applications of the antimicrobial photodynamic therapy (aPDT) treatment protocol, to systemic doxycycline as adjuvant to scaling and root planing (SRP) on type 2 diabetic patients on clinical, systemic and immune\u2010inflammatory outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty patients with Hba1c &gt;7% were allocated in two groups, SRP\u00a0+\u00a0Doxy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) using systemic doxycycline 100\u00a0mg\/day (14\u00a0days) and SRP\u00a0+\u00a0aPDT (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) with multiple applications (0, 3, 7 and 14\u00a0days). Primary outcome was glycated haemoglobin levels (HbA1c). Clinical parameters: plaque score (PS), bleeding on probe, probing depth, suppuration, gingival recession, and clinical attachment level, percentage of pockets with desired clinical endpoint were measured at baseline and 3\u00a0months after therapy. Cytokine profile was assessed at 0, 1 and 3\u00a0month to measure IL1\u2010\u03b2, TNF\u2010\u03b1 and TGF\u2010\u03b2 on gingival crevicular fluid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant difference was detected on HbA1c, between treatments. The SRP\u00a0+\u00a0aPDT group showed advantage on reducing moderate pockets in single\u2010rooted teeth at 3\u00a0months. SRP\u00a0+\u00a0aPDT presented better results at 3\u00a0months on IL1\u2010\u03b2 levels. There were no significant differences between TNF\u2010\u03b1 and TGF\u2010\u03b2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both treatments improved clinical and systemic outcomes (Hba1c). SRP\u00a0+\u00a0aPDT performed better in moderate probing pocket depth on single\u2010rooted teeth, reduced favourably inflammation in short term, and may be an alternative to systemic antibiotics. (Clinicaltrials.org ID NCT01595594).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12498","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T13:28:46Z","timestamp":1451395726000},"page":"147-155","source":"Crossref","is-referenced-by-count":44,"title":["Antimicrobial photodynamic therapy as an alternative to systemic antibiotics: results from a double\u2010blind, randomized, placebo\u2010controlled, clinical study on type 2 diabetics"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-1364","authenticated-orcid":false,"given":"Umberto D.","family":"Ramos","sequence":"first","affiliation":[{"name":"Department of Bucco\u2010Maxillo\u2010Facial Surgery and Traumatology and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro G.","family":"Ayub","sequence":"additional","affiliation":[{"name":"Department of Bucco\u2010Maxillo\u2010Facial Surgery and Traumatology and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo M.","family":"Reino","sequence":"additional","affiliation":[{"name":"Department of Bucco\u2010Maxillo\u2010Facial Surgery and Traumatology and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio F.M.","family":"Grisi","sequence":"additional","affiliation":[{"name":"Department of Bucco\u2010Maxillo\u2010Facial Surgery and Traumatology and Periodontology School of Dentistry of Ribeirao Preto University of Sao Paulo Ribeir\u00e3o Preto SP 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