{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:46:58Z","timestamp":1770486418342,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371150"],"award-info":[{"award-number":["81371150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this systematic review and meta\u2010analysis was to explore the association between erectile dysfunction (<jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>) and chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) in observational studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A literature search of PubMed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and Cochrane up to and including May 22, 2015, was conducted by two independent reviewers. Statistical analysis was performed using Review Manager 5.3, and the results are expressed as odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s) together with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>s), as determined using a random effects model. Subgroup analysis was performed by age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 250 potentially eligible articles, four studies, involving 38,111 cases and 174,807 controls, were included. Based on random effects meta\u2010analysis, a significant association between <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> was identified (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.07, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.87\u20135.05, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Sensitivity analysis was performed due to the presence of statistically extensive heterogeneity (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a098%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this systematic review revealed a positive association between <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content>; however, because the presence and extent of statistical heterogeneity limits the conclusiveness of our findings, larger and better\u2010controlled studies of socially homogeneous populations as well as pathophysiological studies are required to confirm the relationship between <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ED<\/jats:styled-content> and to explore the biological mechanisms involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12512","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T11:55:52Z","timestamp":1452426952000},"page":"206-215","source":"Crossref","is-referenced-by-count":16,"title":["The association between chronic periodontitis and vasculogenic erectile dysfunction: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Qianting","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Kang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Urology West China Hospital Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Periodontics West China Hospital of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Periodontics West China Hospital of Stomatology Sichuan University Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_6_3_1","first-page":"493","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02426.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00142.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1123"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901425"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000051384.43104.FC"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200502000-00001"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01762.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.068"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300214"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.06.018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1128\/IAI.66.11.5337-5343.1998","article-title":"Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis","volume":"66","author":"Deshpande R. G.","year":"1998","journal-title":"Infection and Immunity"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6879.688"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12039"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00359.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.10.069"},{"key":"e_1_2_6_20_1","first-page":"63","volume-title":"Contemporary Periodontics","author":"Genco R. J.","year":"1990"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_6_22_1","first-page":"305","article-title":"Management of erectile dysfunction","volume":"81","author":"Heidelbaugh J. J.","year":"2010","journal-title":"American Family Physician"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_6_24_1","first-page":"31","article-title":"Are periodontal diseases risk factors for certain systemic disorders \u2013 what matters to medical practitioners?","volume":"9","author":"Jin L. J.","year":"2003","journal-title":"Hong Kong Medical Journal"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67900-1"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01879.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.1.257-267.2002"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.537"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510397194"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01481.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01651.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00601.2005"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2004.10104.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2013.30"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1694"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00641.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2003.04378.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02974.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-119578"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300250-JLR200"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00576.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960271305"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.09.059"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00136.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110049"},{"key":"e_1_2_6_49_1","first-page":"33","article-title":"Effect of androgen deprivation on penile ultrastructure","volume":"5","author":"Shen Z. J.","year":"2003","journal-title":"Asian Journal of Andrology"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01417.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12294"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.07.017"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.142516"},{"key":"e_1_2_6_55_1","first-page":"1075","article-title":"Clinically important factors influencing endothelial function","volume":"7","author":"Vapaatalo H.","year":"2001","journal-title":"Medical Science Monitor"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01141.x"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12512","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T15:04:30Z","timestamp":1696172670000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/jcpe.12512"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12512","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}