{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:57:38Z","timestamp":1789534658917,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004368","name":"Colgate-Palmolive Company","doi-asserted-by":"publisher","award":["NO15768"],"award-info":[{"award-number":["NO15768"]}],"id":[{"id":"10.13039\/100004368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This exploratory randomized, controlled clinical trial sought to evaluate anti\u2010inflammatory and \u2010microbial effects of triclosan during experimental gingivitis as assessed by host response biomarkers and biofilm microbial pathogens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty participants were randomized to triclosan or control dentifrice groups who ceased homecare for 21\u00a0days in an experimental gingivitis (<jats:styled-content style=\"fixed-case\">EG<\/jats:styled-content>) protocol. Plaque and gingival indices and saliva, plaque, and gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) were assessed\/collected at days 0, 14, 21 and 35. Levels and proportions of 40 bacterial species from plaque samples were determined using checkerboard <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> hybridization. Ten biomarkers associated with inflammation, matrix degradation, and host protection were measured from <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and saliva and analysed using a multiplex array. Participants were stratified as \u201chigh\u201d or \u201clow\u201d responders based on gingival index and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> biomarkers and bacterial biofilm were combined to generate receiver operating characteristic curves and predict gingivitis susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences in mean <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> values were observed between groups and non\u2010significant trends of reduction of host response biomarkers with triclosan treatment. Triclosan significantly reduced levels of <jats:italic>A. actinomycetemcomitans<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> during induction of gingivitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Triclosan reduced microbial levels during gingivitis development (ClinicalTrials.gov <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01799226).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12519","type":"journal-article","created":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T15:32:55Z","timestamp":1453995175000},"page":"435-444","source":"Crossref","is-referenced-by-count":15,"title":["Effects of triclosan on host response and microbial biomarkers during experimental gingivitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Brooke A.","family":"Pancer","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kott","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V.","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotinos S.","family":"Panagakos","sequence":"additional","affiliation":[{"name":"Colgate\u2010Palmolive Technology Center Piscataway NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Braun","sequence":"additional","affiliation":[{"name":"Biostatistics Department School of Public Health University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P.","family":"Teles","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry University of North Carolina Chapel Hill NC USA"},{"name":"Department of Applied Oral Sciences The Forsyth Institute Cambridge MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7102-9746","authenticated-orcid":false,"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Kinney","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine Michigan Center for Oral Health Research University of Michigan Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00675.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290705.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01548.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00951.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055265"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0643-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0053"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01793.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01579.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb02090.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5037.2005.00150.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2000.102378"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399908"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.027"},{"key":"e_1_2_7_17_1","first-page":"158","article-title":"Experimental gingivitis studies: effects of triclosan and triclosan\u2010containing dentifrices on dental plaque and gingivitis in three\u2010week randomized controlled clinical trials","volume":"13","author":"Lang N. 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