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The secondary aim was to assess the evolution of periodontal medicine in clinical periodontal research as a whole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>We searched all registration records related to periodontology in the World Health Organization International Clinical Trials Registry Platform. For registration records classified in the field of periodontal medicine, we assigned the 2015 Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> term for the most precisely corresponding systemic condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven systemic conditions have been hypothesized to be linked with periodontal diseases, covering nearly 2% of the diseases indexed in Me<jats:styled-content style=\"fixed-case\">SH<\/jats:styled-content>. In addition to diabetes, cardiovascular disease or preterm birth, other systemic conditions have been the subject of registration records, such as anaemia, liver diseases, dyspepsia or ankylosing spondylitis. A trend towards increasing diversification of systemic conditions has appeared over time. About a third of registration records in clinical periodontal research deals with periodontal medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal medicine now constitutes an important part of clinical periodontal research. Research activity in periodontal medicine has grown continuously since the early 2000s, and exploration of registers gives a useful up\u2010to\u2010date snapshot of this constantly evolving field of research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12534","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T15:14:43Z","timestamp":1455635683000},"page":"390-400","source":"Crossref","is-referenced-by-count":173,"title":["Clinical research activity in periodontal medicine: a systematic mapping of trial registers"],"prefix":"10.1111","volume":"43","author":[{"given":"Paul","family":"Monsarrat","sequence":"first","affiliation":[{"name":"Dental Faculty Department of Anatomical Sciences and Radiology Paul Sabatier University Toulouse University Hospital Toulouse France"},{"name":"CNRS 5273 UMR STROMALab University of Toulouse UPS INSERM U1031 EFS Pyrenees \u2013 Mediterranean Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Blaizot","sequence":"additional","affiliation":[{"name":"University of Lille Dental faculty Place de Verdun F\u201059000 Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"K\u00e9moun","sequence":"additional","affiliation":[{"name":"Dental Faculty Department of Biological Sciences Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ravaud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Paris Descartes University Paris France"},{"name":"INSERM UMR\u20101153 Paris France"},{"name":"Department of Epidemiology Columbia University Mailman School of Public Health New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Nabet","sequence":"additional","affiliation":[{"name":"Dental Faculty Department of Epidemiology and Public Health Paul Sabatier University Toulouse University Hospital Toulouse France"},{"name":"INSERM U1027 Paul Sabatier University Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Sixou","sequence":"additional","affiliation":[{"name":"Dental Faculty Department of Epidemiology and Public Health Paul Sabatier University Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Noel","family":"Vergnes","sequence":"additional","affiliation":[{"name":"Dental Faculty Department of Epidemiology and Public Health Paul Sabatier University Toulouse University Hospital Toulouse France"},{"name":"Division of Oral Health and Society Faculty of dentistry McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0038-1627413","article-title":"Commentaries on \u201cInformatics and medicine: from molecules to populations\u201d","volume":"47","author":"Altman R. 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