{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:29:59Z","timestamp":1787614199840,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan","doi-asserted-by":"crossref","award":["25463243"],"award-info":[{"award-number":["25463243"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan","doi-asserted-by":"crossref","award":["25293427"],"award-info":[{"award-number":["25293427"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Studies demonstrated that periodontitis modulates micro\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      (mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s) expression rates in periodontal tissue. However, the relationship between periodontitis and mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s profile in circulation remains unclear. In this study, we investigated the effects of periodontitis on serum mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s profile in a rat model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      Male Wistar rats (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032, 8\u00a0weeks old) were divided into four groups of eight rats each. The control groups received no treatment for 2 or 4\u00a0weeks. In the other two groups, periodontitis was ligature induced for 2 or 4\u00a0weeks. Serum mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s expression profiles of each group were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ligation around teeth induced periodontal inflammation at 2\u00a0weeks and periodontal tissue destruction at 4\u00a0weeks. Microarray results showed that 25 mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s were expressed with a &lt;0.5 or &gt;2 difference between the control and periodontitis groups at 4\u00a0weeks. Results of real\u2010time\n                      <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                      revealed that the periodontitis group up\u2010regulated expression rates of serum miR\u2010207 and miR\u2010495 at 2\u00a0weeks, and miR\u2010376b\u20103p at 4\u00a0weeks (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Serum mi\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      s (miR\u2010207, miR\u2010495, and miR\u2010376b\u20103p) could be valuable biomarkers for periodontitis.\n                    <\/jats:p>\n                  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