{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:03:33Z","timestamp":1791846213381,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T00:00:00Z","timestamp":1462838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008769","name":"Commission for Young Scientists and Gender Equality, University of Wuerzburg","doi-asserted-by":"crossref","award":["2.2-220.522-97\/15_1"],"award-info":[{"award-number":["2.2-220.522-97\/15_1"]}],"id":[{"id":"10.13039\/501100008769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n This prospective, parallel group, two\u2010armed, double\u2010blind, placebo\u2010controlled randomized trial evaluated the impact of dietary nitrate consumption on gingival inflammation in periodontal recall patients.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n \n Forty\u2010four (23 test\/21 placebo) periodontal recall patients with chronic gingivitis were enrolled. At baseline, gingival index (\n GI<\/jats:styled-content>\n ), plaque control record (\n PCR<\/jats:styled-content>\n ) and salivary nitrate level (\n SNL<\/jats:styled-content>\n ) were recorded, followed by sub\u2010 and supragingival debridement. Subsequently, participants were randomly provided with 100\u00a0ml bottles of a lettuce juice beverage to be consumed 3\u00d7 daily over 14\u00a0days, containing either a standardized amount of nitrate resulting in an intake of approximately 200\u00a0mg nitrate per day (test) or being devoid of nitrate (placebo).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At baseline, mean\n GI<\/jats:styled-content>\n ,\n PCR<\/jats:styled-content>\n and\n SNL<\/jats:styled-content>\n did not differ significantly between the groups. At day 14, mean\n GI<\/jats:styled-content>\n of the test group was significantly reduced compared to baseline and significantly lower (\n p<\/jats:italic>\n \u00a0=\u00a00.002) than in the placebo group (\n GI<\/jats:styled-content>\n 0.3\n versus<\/jats:italic>\n 0.5). Also, mean\n SNL<\/jats:styled-content>\n in the test group was significantly higher than in the placebo group (54.0\u00a0\n \u03bc<\/jats:italic>\n g\/ml\n versus<\/jats:italic>\n 27.8\u00a0\n \u03bc<\/jats:italic>\n g\/ml;\n p<\/jats:italic>\n \u00a0<\u00a00.035). Mean\n PCR<\/jats:styled-content>\n did not change significantly in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Dietary nitrate consumption may be a useful adjunct in the control of chronic gingivitis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jcpe.12542","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T19:47:08Z","timestamp":1457812028000},"page":"603-608","source":"Crossref","is-referenced-by-count":65,"title":["Stimulation of the nitrate\u2010nitrite\u2010\n NO<\/scp>\n \u2010metabolism by repeated lettuce juice consumption decreases gingival inflammation in periodontal recall patients: a randomized, double\u2010blinded, placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Yvonne","family":"Jockel\u2010Schneider","sequence":"first","affiliation":[{"name":"Department of Periodontology University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia K.","family":"Go\u00dfner","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis University of Hohenheim Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"H\u00e4gele","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis University of Hohenheim Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf Martin","family":"Schweiggert","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis University of Hohenheim Stuttgart Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imme","family":"Haubitz","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eigenthaler","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Carle","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis University of Hohenheim Stuttgart Germany"},{"name":"Biological Science Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Schlagenhauf","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital of Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080376"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008872107"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.Supplement_2.S162"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00951.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.11.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0695-546"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2873"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01517.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509337700"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.10.4392"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"The oral bioavailability of sodium nitrite investigated in healthy adult volunteers","author":"Kortboyer J. 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