{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:13:21Z","timestamp":1792512801348,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,7]],"date-time":"2016-05-07T00:00:00Z","timestamp":1462579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Focused question<\/jats:title><jats:p>What is the clinical influence of probiotics as an adjunctive therapy of scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) when compared with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> alone or in combination with placebo in the treatment of chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases were searched up to July 2015. Randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) comparing <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0probiotic <jats:italic>versus<\/jats:italic><jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> were included. <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> reduction and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain were selected as primary outcome variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Independent screening resulted in four eligible publications for the systematic review and three were included in the meta\u2010analysis. Meta\u2010analysis showed a statistically significant <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain (\u22120.42\u00a0mm, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) and bleeding on probing (<jats:styled-content style=\"fixed-case\">BOP<\/jats:styled-content>) reduction (\u221214.66, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.003) for <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0probiotic treatment <jats:italic>versus<\/jats:italic><jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> at short\u2010term. Only a tendency (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.06) has been observed in terms of overall <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> reduction, whereas results were significant when stratified for moderate (\u22120.18, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and deep pockets (\u22120.67, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of this study, the findings of this meta\u2010analysis seem to support the adjunctive use of <jats:italic>L.\u00a0reuteri<\/jats:italic> to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> treatment at short\u2010term, especially in deep pockets. Heterogeneity and limited available data may reduce the impact of these conclusions. Future long\u2010term <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s evaluating the clinical efficacy of adjunctive probiotics to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12545","type":"journal-article","created":{"date-parts":[[2016,3,13]],"date-time":"2016-03-13T00:36:05Z","timestamp":1457829365000},"page":"520-530","source":"Crossref","is-referenced-by-count":168,"title":["Clinical efficacy of probiotics as an adjunctive therapy to non\u2010surgical periodontal treatment of chronic periodontitis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Rodrigo","family":"Martin\u2010Cabezas","sequence":"first","affiliation":[{"name":"Department of Periodontology Dental Faculty University of Strasbourg Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-5930","authenticated-orcid":false,"given":"Jean\u2010Luc","family":"Davideau","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Faculty University of Strasbourg Strasbourg France"},{"name":"INSERM 1109 \u201cOsteoarticular &amp; Dental Regenerative Nanomedicine\u201d Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Tenenbaum","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Faculty University of Strasbourg Strasbourg France"},{"name":"INSERM 1109 \u201cOsteoarticular &amp; Dental Regenerative Nanomedicine\u201d Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7988-2290","authenticated-orcid":false,"given":"Olivier","family":"Huck","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dental Faculty University of Strasbourg Strasbourg France"},{"name":"INSERM 1109 \u201cOsteoarticular &amp; Dental Regenerative Nanomedicine\u201d Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-014-9178-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00350.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.00073.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s2.4.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v1i0.1949"},{"key":"e_1_2_7_8_1","first-page":"CD004622","article-title":"Full\u2010mouth treatment modalities (within 24\u00a0hours) for chronic periodontitis in adults","volume":"4","author":"Eberhard J.","year":"2015","journal-title":"Cochrane Database Systematic Reviews"},{"key":"e_1_2_7_9_1","unstructured":"Food and Agriculture Organization\/World Health Organization. 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