{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:38:03Z","timestamp":1767008283382},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to investigate the levels of 11 oral species in plaque samples and cytokine levels in biofluid samples of patients with idiopathic uveitis (<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>) and systemically healthy individuals (H) with or without gingival inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material &amp; Methods<\/jats:title><jats:p>Twenty\u2010one patients with <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a021), and 22 systemically healthy individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) were enrolled in the study. Clinical periodontal measurements were recorded. Cytokine levels in the biofluid samples were determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Bacterial gene copy numbers were determined by <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> on plaque microbial <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> preparations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to two\u2010step cluster analysis, <jats:sc>anova<\/jats:sc> and <jats:italic>t<\/jats:italic>\u2010test: <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>, serum and salivary <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u201017A, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\/E; <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106; salivary <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017F, and salivary and serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\/F levels were higher in the <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> group than the H group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). However, serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017E levels were higher in the H group than the <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). <jats:italic>A.\u00a0actinomycetemcomitans, F.\u00a0nucleatum, S.\u00a0oralis, A.\u00a0naeslundii<\/jats:italic>, and <jats:italic>V.\u00a0dispar<\/jats:italic> counts were higher in <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> group compared to H group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altered local and systemic cytokine profiles are associated with differences in the microbial plaque composition in <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>. Anti\u2010inflammatory cytokines; <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017E are reduced in patients with <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> and Th\u20101 and Th\u201017 driven inflammatory responses in biofluids are altered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12555","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:30:24Z","timestamp":1459384224000},"page":"637-645","source":"Crossref","is-referenced-by-count":6,"title":["Effect of gingival inflammation on the inflammatory response in patients with idiopathic uveitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Aliye","family":"Akcal\u0131","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzan","family":"G\u00fcven Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Lappin","sequence":"additional","affiliation":[{"name":"Infection and Immunity Group Dental Hospital and School School of Medicine College of Medical, Veterinary and Life Sciences University of Glasgow Glasgow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sait","family":"E\u011frilmez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Faculty of Medicine Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12238"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090185"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510376402"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.06.014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.85"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0042"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.033"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2013.58"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008289200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.255"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0810456"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515591790"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1544-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079903125002847"},{"key":"e_1_2_6_21_1","first-page":"2970","article-title":"The role of toll\u2010like receptor variants in acute anterior uveitis","volume":"17","author":"Pratap D. 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