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Database searches up to December 2015, and manual search of the reference list from reviews and selected articles was performed. Only studies providing data on <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> cytokines\/chemokines levels in subjects diagnosed with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>h<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> and periodontally healthy controls were included. Cross\u2010sectional, case series, single\u2010arm clinical studies, randomized controlled trials and prospective\/retrospective cohort studies were included. Meta\u2010analyses were conducted for those cytokines\/chemokines with at least three available studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010<jats:italic>\u03b3<\/jats:italic> and <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2 were significantly higher in subjects diagnosed with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>h<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> than periodontally healthy subjects. A significant decrease in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 was observed after non\u2010surgical periodontal treatment, whereas a significant increase was observed for <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evidence for significant differences between periodontal health and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>h<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content> was observed for a few cytokines and one chemokine. 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