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The primary outcome variable was the difference (\u0394) in the number of sites with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u00a0\u2265\u00a06\u00a0mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one patients completed the study. At both 3 and 6\u00a0months, all three treatment protocols resulted in statistically significant improvements compared to baseline for all evaluated clinical parameters (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). At 6\u00a0months, a\u00a0statistically significantly greater reduction in the mean number of sites with <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\u00a0\u2265\u00a06\u00a0mm was observed in group B (28.62\u00a0\u00b1\u00a015.32 sites) and group C (30.45\u00a0\u00b1\u00a015.04 sites) compared to the placebo group (17.10\u00a0\u00b1\u00a014.68 sites). Furthermore, both the 3\u2010 and the 7\u2010day antibiotic regimen resulted in statistically significantly higher clinical improvements compared to the placebo group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings indicate that in patients with severe chronic periodontitis, non\u2010surgical periodontal therapy in conjunction with a 3 or 7\u00a0days systemic administration of <jats:styled-content style=\"fixed-case\">AMX<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">MET<\/jats:styled-content> may lead to significantly greater clinical improvements compared to non\u2010surgical therapy alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12559","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:27:18Z","timestamp":1459384038000},"page":"767-777","source":"Crossref","is-referenced-by-count":35,"title":["Non\u2010surgical periodontal treatment in conjunction with 3 or 7\u00a0days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. 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