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Whole blood was stimulated for 24\u00a0h with plaque samples generated from healthy or diseased sites. The levels of 14\u00a0cyto\/chemokines were detected using multiplex technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Localized aggressive periodontitis\u2010derived cultures displayed higher levels of <jats:styled-content style=\"fixed-case\">G\u2010CSF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> INF<\/jats:styled-content><jats:italic>\u03b3<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>10, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>12p40, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>1<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MIP<\/jats:styled-content>\u20101<jats:italic>\u03b1<\/jats:italic>, and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content><jats:italic>\u03b1<\/jats:italic>, than control cultures regardless of stimulus used. Whole blood from healthy siblings displayed higher levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 compared to control subjects, but lower levels than those observed in cultures from <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that although bacteria is an important factor in eliciting the hyper\u2010inflammatory response observed in <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> patients, the predisposition of host's response to bacterial presence may play a more significant role than the components of the stimulatory plaque.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12560","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T20:41:52Z","timestamp":1459629712000},"page":"746-753","source":"Crossref","is-referenced-by-count":35,"title":["Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque"],"prefix":"10.1111","volume":"43","author":[{"given":"Luciana M.","family":"Shaddox","sequence":"first","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"},{"name":"Department of Oral Biology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Velsko","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Al\u2010Kassab","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Calderon","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikramuddin","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Wallet","sequence":"additional","affiliation":[{"name":"Department of Oral Biology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290108.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00350.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060129"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090185"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00777.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.2.279"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01012-14"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.66"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.9.5089-5096.2004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-1065-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.6.623"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.254"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00717.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2001.00210.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-206"},{"key":"e_1_2_6_19_1","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. 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