{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:11:43Z","timestamp":1778652703292,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008978","name":"Philips Oral Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001827","name":"Universiteit van Amsterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinical and microbiological effects of local disinfection with 0.5% sodium hypochlorite (NaOCl) with or without systemic antimicrobials (amoxicillin and metronidazole, AM) during basic periodontal therapy (BPT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In a randomized clinical trial (four groups), 110 chronic periodontitis patients received BPT plus local irrigation with saline (BPT\u00a0+\u00a0S), local disinfection with NaOCl (BPT\u00a0+\u00a0DIS), BPT\u00a0+\u00a0DIS\u00a0+\u00a0AM or BPT\u00a0+\u00a0S\u00a0+\u00a0AM. The outcome was analysed at baseline, 3, 6 and 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in clinical attachment level gain at 12\u00a0months between the four groups. BPT\u00a0+\u00a0DIS showed no additional improvement compared to BPT\u00a0+\u00a0S; BPT\u00a0+\u00a0DIS\u00a0+\u00a0AM showed fewer sites with probing pocket depth (PPD) \u22657\u00a0mm <jats:italic>versus<\/jats:italic> BPT\u00a0+\u00a0S only up to 6\u00a0months (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.037). In factorial analyses, additional clinical reduction for PPD (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023) and number of sites with PPD \u22655 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007), \u22656 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002) and \u22657\u00a0mm (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) were found when AM was added to BPT, but not when DIS was applied. In all groups, a comparable decrease in targeted bacteria was found. AM caused adverse events in 22% of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Local disinfection with NaOCl, also in combination with AM, showed, after 1\u2010year follow\u2010up, no additional clinical and microbiological effects compared to BPT alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12578","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T07:19:51Z","timestamp":1463037591000},"page":"778-788","source":"Crossref","is-referenced-by-count":24,"title":["Local disinfection with sodium hypochlorite as adjunct to basic periodontal therapy: a randomized controlled trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Sergio","family":"Bizzarro","sequence":"first","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry of Amsterdam (ACTA) University of Amsterdam and VU University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubele","family":"Van der Velden","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry of Amsterdam (ACTA) University of Amsterdam and VU University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno G.","family":"Loos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Academic Centre for Dentistry of Amsterdam (ACTA) University of Amsterdam and VU University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.03.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080540"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.5.749"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-0420.2007.00952.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130278"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12075"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02459.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12151"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12219"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01870.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2011.191"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr302"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00765.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01260.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.2.63"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12221"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01927.x"},{"key":"e_1_2_6_20_1","first-page":"7","article-title":"Periodontal risk assessment (PRA) for patients in supportive periodontal therapy (SPT)","volume":"1","author":"Lang N. P.","year":"2003","journal-title":"Oral Health and Preventive Dentistry"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.9.564"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2106"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01323.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v4i0.17535"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb02068.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01249.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1530-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01681.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.839"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00287.x"},{"key":"e_1_2_6_31_1","first-page":"23","article-title":"A clinico\u2010morphological assessment of the efficacy of sodium hypochlorite in the combined therapy of periodontitis","volume":"69","author":"Perova M. D.","year":"1990","journal-title":"Stomatologiia (Mosk)"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00871.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080403"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01256.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110625"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12089"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00004.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.24.4.638-644.1972"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(03)00360-3"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028004296.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291107.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01626.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120040"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12578","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T17:47:35Z","timestamp":1696182455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jcpe.12578"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12578","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}