{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:46:29Z","timestamp":1787579189385,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to compare the results obtained with enamel matrix derivative (<jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>\u00a0+\u00a0platelet\u2010rich fibrin (<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) in the treatment of intrabony defects (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>s) in chronic periodontitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Using a split\u2010mouth design, 28 paired <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>s were randomly treated either with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> or with <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>. Clinical and radiographic measurements including clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), gingival recession (<jats:styled-content style=\"fixed-case\">GR<\/jats:styled-content>), defect depth (<jats:styled-content style=\"fixed-case\">DD<\/jats:styled-content>), defect width (<jats:styled-content style=\"fixed-case\">DW<\/jats:styled-content>) and defect angle (<jats:styled-content style=\"fixed-case\">DA<\/jats:styled-content>) were recorded at baseline (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) and at six\u00a0months following therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> clinical and radiographic measurements were similar for <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> groups. Although postsurgical measurements revealed significant reduction for <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> in both groups, no intergroup difference was detected. When <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EMD<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> groups were compared, defect fill was not also statistically different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both therapies resulted in significant clinical improvement in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> treatment. Addition of <jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> did not improve the clinical and radiographic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12598","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T04:32:37Z","timestamp":1468211557000},"page":"955-964","source":"Crossref","is-referenced-by-count":41,"title":["Evaluation of the adjunctive effect of platelet\u2010rich fibrin to enamel matrix derivative in the treatment of intrabony defects. 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