{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:02:12Z","timestamp":1788555732370,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This randomized controlled trial assessed the impact of\n                      <jats:italic>Lactobacillus reuteri<\/jats:italic>\n                      on pregnancy gingivitis in healthy women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five healthy women (24 test\/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      ) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      analysis. Subsequently participants were randomly provided with lozenges to be consumed 2\u00a0\u00d7 daily until birth (approx. 7\u00a0weeks) containing \u226510\n                      <jats:sup>8<\/jats:sup>\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">ATCC PTA<\/jats:styled-content>\n                      5289 and \u226510\n                      <jats:sup>8<\/jats:sup>\n                      <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">DSM<\/jats:styled-content>\n                      17938 (test) or being devoid of\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      (placebo). Within 2 days after birth recording of\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      , PlI and blood sampling were repeated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, mean\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      and mean PlI did not differ significantly between both groups. In the test group mean\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      serum level was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.02) lower than in the placebo group. At reevaluation, mean\n                      <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>\n                      and mean PlI of the test group were both significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) lower than in the placebo group. Mean\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\n                      <jats:italic>\u03b1<\/jats:italic>\n                      serum level did no longer differ significantly between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The consumption of\n                      <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                      lozenges may be a useful adjunct in the control of pregnancy gingivitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12606","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T07:52:40Z","timestamp":1469605960000},"page":"948-954","source":"Crossref","is-referenced-by-count":65,"title":["Regular consumption of Lactobacillus reuteri\u2010containing lozenges reduces pregnancy gingivitis: an\n                    <scp>RCT<\/scp>"],"prefix":"10.1111","volume":"43","author":[{"given":"Ulrich","family":"Schlagenhauf","sequence":"first","affiliation":[{"name":"Department of Periodontology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eigenthaler","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Segerer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Jockel\u2010Schneider","sequence":"additional","affiliation":[{"name":"Department of Periodontology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Rehn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12180"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-014-9178-y"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJICMR.S22848"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00951.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00525.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12082"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2015.09.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.10.4325-4333.2000"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734406"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01914.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140248"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1980.tb00265.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2011.00398.x"},{"key":"e_1_2_6_15_1","first-page":"169","article-title":"Occurrence of socransky red complex in pregnant women with and without periodontal disease","volume":"13","author":"Lima D. P.","year":"2015","journal-title":"Oral Health & Preventive Dentistry"},{"key":"e_1_2_6_16_1","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene R. R.","year":"1986","journal-title":"Clinical Preventive Dentistry"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ebd.6400966"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078898"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.3.211"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb01172.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00468.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2010.77"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2690"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354412"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.12.1854"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12387"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12155"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802516170"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/623427"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.12606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.12606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T13:38:12Z","timestamp":1694871492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.12606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jcpe.12606"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.12606","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,12]]}}}