{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:30:14Z","timestamp":1792081814431,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:00:00Z","timestamp":1474416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the influence of the use L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> as a socket filling material and its ridge preservation properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010two patients in need of single bilateral and closely symmetrical tooth extractions in the maxilla or mandible were included in a split\u2010mouth <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>. Treatments were randomly assigned (L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> socket filling <jats:italic>versus<\/jats:italic> natural healing). <jats:styled-content style=\"fixed-case\">CBCT<\/jats:styled-content> scans were obtained after tooth extraction and three\u00a0months. Scans were evaluated by superimposition using the original <jats:styled-content style=\"fixed-case\">DICOM<\/jats:styled-content> data. Mean ridge width differences between timepoints were measured at three levels below the crest on both the buccal and lingual sides (crest \u22121\u00a0mm (primary outcome variable), \u22123\u00a0mm and \u22125\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean vertical height changes at the buccal were \u22121.5\u00a0mm (\u00b11.3) for control sites and 0.5\u00a0mm (\u00b12.3) for test sites (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005). At the buccal side, control sites values were, respectively, \u22122.1 (\u00b12.5), \u22120.3\u00a0mm (\u00b10.3) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005) and \u22120.1\u00a0mm (\u00b10.0), and test sites values were, respectively, \u22120.6\u00a0mm (\u00b12.2) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005), \u22120.1\u00a0mm (\u00b10.3) and 0.0\u00a0mm (\u00b10.1). Significant differences (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.005) were found for total width reduction between test (\u221222.84%) and control sites (\u221251.92%) at 1\u00a0mm below crest level. Significant differences were found for socket fill (visible mineralized bone) between test (94.7%) and control sites (63.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> as a socket filling material to achieve preservation of horizontal and vertical ridge dimension at three \u00a0months after tooth extraction is beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12612","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T12:53:36Z","timestamp":1470833616000},"page":"990-999","source":"Crossref","is-referenced-by-count":168,"title":["The use of leucocyte and platelet\u2010rich fibrin in socket management and ridge preservation: a split\u2010mouth, randomized, controlled clinical trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Andy","family":"Temmerman","sequence":"first","affiliation":[{"name":"Section\u00a0of Periodontology Department of Oral Health Sciences KU Leuven and Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Vandessel","sequence":"additional","affiliation":[{"name":"OMFS\u2010Impath Research Group Department of Oral and Maxillofacial Surgery University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Castro","sequence":"additional","affiliation":[{"name":"Section\u00a0of Periodontology Department of Oral Health Sciences KU Leuven and Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhilde","family":"Jacobs","sequence":"additional","affiliation":[{"name":"OMFS\u2010Impath Research Group Department of Oral and Maxillofacial Surgery University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Teughels","sequence":"additional","affiliation":[{"name":"Section\u00a0of Periodontology Department of Oral Health Sciences KU Leuven and Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Oral Implantology University De Los Andes Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[{"name":"Section\u00a0of Periodontology Department of Oral Health Sciences KU Leuven and Dentistry University Hospitals KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12366"},{"key":"e_1_2_6_3_1","first-page":"9","article-title":"Socket grafting with the use of autologous bone: an experimental study in the dog","volume":"22","author":"Ara\u00fajo M. 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