{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:26:46Z","timestamp":1788848806158,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T00:00:00Z","timestamp":1476662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Scientific Research Projects of Afyon Kocatepe University","award":["14.D\u0130\u015e.01"],"award-info":[{"award-number":["14.D\u0130\u015e.01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional study aims to analyse cortisol and dehydroepiandrosterone (<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>) levels in gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) and saliva in generalized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>) and generalized chronic periodontitis (<jats:styled-content style=\"fixed-case\">GCP<\/jats:styled-content>) patients, as well as in periodontally healthy individuals (C).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>A total of 92 patients (31 C, 34<jats:styled-content style=\"fixed-case\">GCP<\/jats:styled-content>and 27<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>) were included in the study. Clinical parameters including plaque index, gingival index, bleeding on probing, probing depth and clinical attachment level; psychosocial measurements including Beck depression inventory and state\u2010trait anxiety inventory; and hormone levels in<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>and saliva including cortisol and<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gingival crevicular fluid cortisol and<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>\/saliva<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>values were significantly higher in the<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>group when compared to the other two groups (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). The lowest values were in the C group and the difference between the<jats:styled-content style=\"fixed-case\">GCP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>groups was statistically significant (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Salivary cortisol levels were comparable for the<jats:styled-content style=\"fixed-case\">GAP<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">GCP<\/jats:styled-content>groups (<jats:italic>p\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.05), and the C group had the lowest values in comparison with the other two groups (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limits of this study, salivary\/<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>cortisol and<jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content>levels were suggested to be related with more severe and aggressive forms of periodontal disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12614","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T14:00:26Z","timestamp":1470924026000},"page":"1024-1031","source":"Crossref","is-referenced-by-count":36,"title":["Gingival crevicular fluid and saliva stress hormone levels in patients with chronic and aggressive periodontitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Omer","family":"Cakmak","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Afyon Kocatepe University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekeriya","family":"Tasdemir","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Erciyes University Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuneyt Asim","family":"Aral","sequence":"additional","affiliation":[{"name":"Oral and Dental Health Center Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Dundar","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Firat University Elaz\u0131g Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halit Bugra","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry Faculty of Medicine Afyon Kocatepe University Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2012.02341.x"},{"key":"e_1_2_7_3_1","first-page":"1075","article-title":"Neuroimmune mechanisms in health and disease: 2. 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