{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:20:39Z","timestamp":1791357639196,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich"},{"name":"Geistlich Pharma AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to test whether or not a collagen matrix can improve early wound healing compared to spontaneous healing based on histological and immunohistologic analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 20 volunteers, 6\u00a0mm punch biopsies were harvested at the palate. A xenogeneic collagen matrix (<jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>) was sutured in one site; the other one was left untreated (control). Biopsies with a diameter of 8\u00a0mm were subsequently obtained at 4, 8, 15 and 29\u00a0days and histological and immunohistologic analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At day 4, wound bed keratinization amounted to 12.4\u00a0\u00b1\u00a07.5% (control) and 18.0\u00a0\u00b1\u00a010.2% (<jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>). This increased up to day 8 (19.7\u00a0\u00b1\u00a025.5% control; 29.1\u00a0\u00b1\u00a08.0% <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>) and reached complete keratinization at day 15 in both groups. The quantitative analyses of the superficial compartment measured an increase in the amount of granulation tissue (32\u201388% control; 14\u201341% <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content>) from day 4 to day 8. Angiogenesis was first detected at 8\u00a0days. At day 29, the amount of connective tissue in all compartments reached values similar to the native tissue at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The application of a <jats:styled-content style=\"fixed-case\">XCM<\/jats:styled-content> as a wound dressing on palatal wounds might be beneficial in the early stages of wound healing. Further research with a larger sample size is needed to confirm these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12624","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T12:02:53Z","timestamp":1473681773000},"page":"1124-1131","source":"Crossref","is-referenced-by-count":28,"title":["Palatal wound healing using a xenogeneic collagen matrix \u2013 histological outcomes of a randomized controlled clinical trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Daniel S.","family":"Thoma","sequence":"first","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Hilbe","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Bienz","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Sancho\u2010Puchades","sequence":"additional","affiliation":[{"name":"Clinic of Fixed and Removable Prosthodontics and Dental Material Science Center of Dental Medicine University of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph H. 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