{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:55Z","timestamp":1790395135202,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/01930\u20103"],"award-info":[{"award-number":["2010\/01930\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/23767\u20105"],"award-info":[{"award-number":["2013\/23767\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Based on periodontal parameters, body mass index and waist\u2010hip ratio, 166 patients were allocated into one of the following groups: Normal weight (\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      ) patients with periodontal health (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a044),\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      patients with\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040), obese patients with periodontal health (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040) and obese patients with\u00a0\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042). Six subgingival biofilm samples per patient were analysed for\u00a0their\u00a0content of 40 bacterial species using checkerboard\n                      <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                      hybridization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Obese patients with\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      harboured higher levels and\/or higher proportions of several periodontal pathogens than those with\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      , including\n                      <jats:italic>Aggregatibacter actinomycetemcomitans, Eubacterium nodatum<\/jats:italic>\n                      ,\n                      <jats:italic>Fusobacterium nucleatum ss vincentii, Parvimonas micra<\/jats:italic>\n                      ,\n                      <jats:italic>Prevotella intermedia<\/jats:italic>\n                      ,\n                      <jats:italic>Tannerella forsythia, Prevotella melaninogenica<\/jats:italic>\n                      and\n                      <jats:italic>Treponema socranskii<\/jats:italic>\n                      . The proportions of most of these pathogens, as well\n                      <jats:italic>Campylobacter rectus<\/jats:italic>\n                      and\n                      <jats:italic>Eikenella corrodens,<\/jats:italic>\n                      were more increased in the diseased sites of the obese patients than in those with\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      . Furthermore, the healthy sites of the obese patients, presenting or not\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      , also exhibited higher proportions of some of the pathogens than patients with\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Obesity is associated with increased levels and proportions of periodontal pathogens, especially in patients with\n                      <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12634","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T01:33:41Z","timestamp":1476322421000},"page":"1003-1012","source":"Crossref","is-referenced-by-count":93,"title":["Does obesity influence the subgingival microbiota composition in periodontal health and disease?"],"prefix":"10.1111","volume":"43","author":[{"given":"Suellen Silva","family":"Maciel","sequence":"first","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Eduardo Dias","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Santos","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"},{"name":"Department of Dentistry Federal University of Santa Catarina Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Doyle Pereira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Public Health Department University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poliana Mendes","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Periodontology Guarulhos University S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12125"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100321"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01356.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000301"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.15-19"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01538.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12417"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511425045"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.12.022"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0897-4_14"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_5_15_1","first-page":"788","article-title":"\u201cCheckerboard\u201d DNA\u2010DNA hybridization","volume":"17","author":"Socransky S. 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