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On days 1, 3, 7, and 15,\u00a0following baseline, nine animals from each experimental group were killed. Bone volume fraction (<jats:styled-content style=\"fixed-case\">BVF<\/jats:styled-content>) and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) were measured using micro\u2010computed tomography. Expression and synthesis profile of cytokines and receptors of inflammation in gingival tissues were evaluated by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> array assay and multiplex immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 15\u00a0days, the <jats:styled-content style=\"fixed-case\">OMP<\/jats:styled-content> group presented a significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) lower <jats:styled-content style=\"fixed-case\">BVF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> levels when compared to all the other groups. The <jats:styled-content style=\"fixed-case\">OMP<\/jats:styled-content> group presented the highest number of upregulated protein targets in comparison to the other groups. Furthermore, the gene expression and protein levels of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>1\u2010<jats:italic>\u03b1<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> IL<\/jats:styled-content>\u201018, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>, and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> were significantly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) higher in the <jats:styled-content style=\"fixed-case\">OMP<\/jats:styled-content> group when compared to the P group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, mechanical loading modulates the inflammatory response of periodontal tissues to periodontal disease by increasing the expression of several pro\u2010inflammatory mediators and receptors, which leads to increased bone resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12636","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T05:38:36Z","timestamp":1476337116000},"page":"31-41","source":"Crossref","is-referenced-by-count":53,"title":["Contribution of biomechanical forces to inflammation\u2010induced bone resorption"],"prefix":"10.1111","volume":"44","author":[{"given":"Andressa Vilas Boas","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery School of Dentistry at Araraquara Univ Estadual Paulista (UNESP) Araraquara S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-6233","authenticated-orcid":false,"given":"Rafael Scaf","family":"de 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