{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:11:06Z","timestamp":1783015866295,"version":"3.54.6"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:00Z","timestamp":1482796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE019456"],"award-info":[{"award-number":["R01DE019456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R90DE22530\u20104"],"award-info":[{"award-number":["R90DE22530\u20104"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate long\u2010term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (<jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred forty\u2010one African Americans diagnosed with <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content>, aged 5\u201325\u00a0years, were enrolled. Patients underwent periodontal mechanical debridement plus 1 week of amoxicillin\/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18 and 24\u00a0months, and two additional annual follow\u2010up visits after treatment. Radiographs from primary dentition of patients with <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> in permanent dentition, and additional healthy siblings (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) were analysed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontal therapy significantly improved probing depth and clinical attachment level up to 4\u00a0years (mean reductions: 2.18\u00a0\u00b1\u00a01.03 and 2.80\u00a0\u00b1\u00a01.43\u00a0mm, respectively). Percentage of affected sites was reduced at all time points and maintained up to 4\u00a0years. Non\u2010compliance with antibiotics\/appointments negatively affected the treatment response. Ninety per cent of <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> patients in permanent dentition and 32% of <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> presented radiographic bone loss in primary dentition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mechanical debridement with 1 week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> for up to 4\u00a0years. <jats:styled-content style=\"fixed-case\">LAP<\/jats:styled-content> in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>01330719.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12640","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T11:01:06Z","timestamp":1477047666000},"page":"158-168","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study"],"prefix":"10.1111","volume":"44","author":[{"given":"Karina A. F. S.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana S.","family":"Branco\u2010de\u2010Almeida","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"},{"name":"Department of Dentistry II School of Dentistry Federal University of Maranh\u00e3o S\u00e3o Lu\u00eds MA Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hovencamp","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Treloar","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"},{"name":"Division of Restorative Dentistry &amp; Periodontology Dublin Dental University Hospital Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikramuddin","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics College of Pharmacy University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana M.","family":"Shaddox","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/21505594.2014.982428"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290108.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1971.42.8.516"},{"key":"e_1_2_6_7_1","first-page":"b97","article-title":"Analysis of clinical results of systemic antimicrobials combined with nonsurgical periodontal treatment for generalized aggressive periodontitis: a pilot study","volume":"77","author":"Baltacioglu E.","year":"2011","journal-title":"Journal\/Canadian Dental Association. 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