{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:20:33Z","timestamp":1791314433940,"version":"4.3.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To analyse the regenerative potential of leucocyte\u2010 and platelet\u2010rich fibrin (L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content>) during periodontal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow\u2010up limitation was applied. Pocket depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), bone fill, keratinized tissue width (<jats:styled-content style=\"fixed-case\">KTW<\/jats:styled-content>), recession reduction and root coverage (%) were considered as outcome. When possible, meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra\u2010bony defects (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>s), furcation defects and periodontal plastic surgery. Meta\u2010analysis was performed in all the subgroups. Significant <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction (1.1\u00a0\u00b1\u00a00.5\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain (1.2\u00a0\u00b1\u00a00.6\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and bone fill (1.7\u00a0\u00b1\u00a00.7\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were found when comparing L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> to open flap debridement (<jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>s. For furcation defects, significant <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction (1.9\u00a0\u00b1\u00a01.5\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01), <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain (1.3\u00a0\u00b1\u00a00.4\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and bone fill (1.5\u00a0\u00b1\u00a00.3\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) were reported when comparing L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">OFD<\/jats:styled-content>. When L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> was compared to a connective tissue graft, similar outcomes were recorded for <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction (0.2\u00a0\u00b1\u00a00.3\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05), <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain (0.2\u00a0\u00b1\u00a00.5\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05), <jats:styled-content style=\"fixed-case\">KTW<\/jats:styled-content> (0.3\u00a0\u00b1\u00a00.4\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05) and recession reduction (0.2\u00a0\u00b1\u00a00.3\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>L\u2010<jats:styled-content style=\"fixed-case\">PRF<\/jats:styled-content> enhances periodontal wound healing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12643","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T07:42:59Z","timestamp":1479973379000},"page":"67-82","source":"Crossref","is-referenced-by-count":219,"title":["Regenerative potential of leucocyte\u2010 and platelet\u2010rich fibrin. 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