{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:19:01Z","timestamp":1769149141125,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program of the National Research Foundation of Korea (NRF)","award":["NRF-2014R1A1A1A05002953"],"award-info":[{"award-number":["NRF-2014R1A1A1A05002953"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the effect of fibroblast growth factor\u20102 (<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102) in combination with porcine collagen matrix (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) for coverage of gingival recession defects in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In five male mongrel dogs, labial gingival recession defects were surgically created in the lower\u2010third incisors bilaterally. The defects were randomly assigned to the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 group (experimental) or the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010only group (control). Standardized clinical photographs and silicone impressions were taken at 4 and 16\u00a0weeks of healing to calculate the remaining recession area. The dogs were euthanized after 16\u00a0weeks for histometric analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u00a0weeks, the recession area of the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 group was significantly smaller than that of the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010only group (2.55\u00a0\u00b1\u00a00.66 and 4.92\u00a0\u00b1\u00a01.05\u00a0mm<jats:sup>2<\/jats:sup>, respectively, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023), However, no significant difference was observed at 16\u00a0weeks. Histometrically, the amount of newly formed cementum was larger in the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 group than in the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010only group at 16\u00a0weeks (1.55\u00a0\u00b1\u00a00.44 and 0.88\u00a0\u00b1\u00a00.51\u00a0mm, respectively, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.024).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\u20102 may enhance the early wound healing and may promote cementum formation to a higher extent compared to the use of <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12644","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T07:42:59Z","timestamp":1479973379000},"page":"96-103","source":"Crossref","is-referenced-by-count":14,"title":["Root coverage using porcine collagen matrix with fibroblast growth factor\u20102: a pilot study in dogs"],"prefix":"10.1111","volume":"44","author":[{"given":"Jae Kook","family":"Cha","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo\u2010Kyung","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 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