{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:27:19Z","timestamp":1757543239560,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007650","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riliitto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64\u00a0years, dentate, non\u2010diabetic and non\u2010rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4\u00a0mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin\u20106 (IL\u20106) and tumour necrosis factor alpha (TNF\u2010\u03b1). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of teeth with deepened periodontal pockets was associated with elevated serum IL\u20106 levels among subjects with an unfavourable lipid composition (low\u2010density lipoprotein cholesterol \u22653.7\u00a0mmol\/l or high\u2010density lipoprotein cholesterol &lt;1.3\u00a0mmol\/l). There was no association between serum TNF\u2010\u03b1 levels and the number of teeth with deepened periodontal pockets in these data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.12688","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T14:22:58Z","timestamp":1483021378000},"page":"275-282","source":"Crossref","is-referenced-by-count":3,"title":["Serum lipids modify periodontal infection \u2013 interleukin\u20106 association"],"prefix":"10.1111","volume":"44","author":[{"given":"Anniina","family":"Haro","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"City of \u00c4\u00e4nekoski, Public Health Centre, Oral Health Care Services \u00c4\u00e4nekoski Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"Saxlin","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Surgery Kuopio University Hospital Kuopio Finland"},{"name":"Institute of Dentistry University of Oulu Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-0055","authenticated-orcid":false,"given":"Anna Liisa","family":"Suominen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Surgery Kuopio University Hospital Kuopio Finland"},{"name":"The Living Environment and Health Unit National Institute for Health and Welfare Kuopio Finland"},{"name":"The Health Monitoring Unit National Institute for Health and Welfare Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Jula","sequence":"additional","affiliation":[{"name":"National Institute for Health and Welfare (THL) Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Knuuttila","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Oulu Oulu Finland"},{"name":"Unit of Oral Health Sciences Medical Research Center Oulu (MRC Oulu) Oulu University Hospital and Oulu University Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Yl\u00f6stalo","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Eastern Finland Kuopio Finland"},{"name":"Department of Oral and Maxillofacial Surgery Kuopio University Hospital Kuopio Finland"},{"name":"Unit of Oral Health Sciences Medical Research Center Oulu (MRC Oulu) Oulu University Hospital and Oulu University Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110646"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100425"},{"volume-title":"Health and Functional Capacity in Finland. 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