{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:08:11Z","timestamp":1787015291749,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2012M3A9B2052521"],"award-info":[{"award-number":["2012M3A9B2052521"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The present study aimed to characterize the expression pattern of chemokines obtained from inflamed periodontal defects and to determine the characteristics of human periodontal\u2010ligament stem cells (\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s) migrated by each specific chemokine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Both inflamed and healthy periodontal tissues were obtained from periodontitis patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011), and the chemokine expression levels were analyzed. The periodontal\u2010tissue\u2010specific chemokines were applied to healthy\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s from extracted teeth (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      3), with\n                      <jats:styled-content style=\"fixed-case\">FGF<\/jats:styled-content>\n                      \u20102 acting as a positive control. Cells were separated by selected chemokines using transwell method into migrated\/unmigrated\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s. The characteristics of the\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      subpopulation recruited by each chemokine were assessed, and gene expression pattern was analyzed by microarray.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Chemokines were categorized into three groups by specific patterns of \u201cappearing,\u201d \u201cincreasing,\u201d and \u201cdecreasing\/disappearing\u201d from healthy to inflamed tissues. A representative chemokine from each group enhanced the capacities for colony formation and osteogenic\/adipogenic differentiation while maintaining the surface markers of\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s.\n                      <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\n                      5 significantly increased the cellular migration of\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s, via enhancement of signaling pathways, regulation of the actin skeleton, and focal adhesion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The present study found a specific chemokine profile induced by inflammation in periodontal tissues, with\n                      <jats:styled-content style=\"fixed-case\">RANTES<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>\n                      5 appearing to play a role in the migration of\n                      <jats:styled-content style=\"fixed-case\">hPDLSC<\/jats:styled-content>\n                      s into inflammatory periodontal lesions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.12710","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T16:17:10Z","timestamp":1487261830000},"page":"530-539","source":"Crossref","is-referenced-by-count":24,"title":["Chemokine in inflamed periodontal tissues activates healthy periodontal\u2010ligament stem cell migration"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5978","authenticated-orcid":false,"given":"Jung\u2010Seok","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Kook","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Periodontology Research Institute for Periodontal Regeneration College of Dentistry Yonsei University Seoul 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